Registration Dossier
Registration Dossier
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EC number: 203-629-0 | CAS number: 108-91-8
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- other: relationship cyclohexylamine and cyclamate
- Adequacy of study:
- other information
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The metabolism of cyclamate to cyclohexylamine in humans during long-term administration
- Author:
- Renwick AG et al
- Year:
- 2 004
- Bibliographic source:
- Toxicol appl Pharmacol 196, 367-380
- Reference Type:
- publication
- Title:
- In vivo conversion of C-labelled cyclamate to cyclohexylamine
- Author:
- Parosky L et al
- Year:
- 1 971
- Bibliographic source:
- J Pharmacol Sci 60, 1341-2343
- Reference Type:
- publication
- Title:
- The metabolism of cyclamates in rats
- Author:
- Wallace WC, Kethco EJ, Brouwer EA
- Year:
- 1 970
- Bibliographic source:
- J Pharmacol Exp Toxicol 175, 325-330
- Reference Type:
- publication
- Title:
- a 7-month study of ingestion of socium cyclamate by human volunteers
- Author:
- Wills JH, Serrone DM, Coulston F
- Year:
- 1 981
- Bibliographic source:
- Regul toxicol Oharmacol 1, 163-176
- Reference Type:
- publication
- Title:
- Beitrag zur hygienischen Beurteilung von Cyclamat
- Author:
- Wolf A et al
- Year:
- 1 971
- Bibliographic source:
- Die Nahrung 15, 363.366
- Reference Type:
- publication
- Title:
- Long-term toxicits and carcinogenicity study of cyclamate in nonhuman primates
- Author:
- Takayama S, Renwick AG, Johansson SL, Thorgeirsson UP, Tsutsumi M, Dalgard DW, Sieber SM
- Year:
- 2 000
- Bibliographic source:
- Tox Sci 53, 33-39
- Reference Type:
- publication
- Title:
- Cyclamate intake and cyclohexylamine excretion are not related to male fertility in humans
- Author:
- Serra-Majem L et al
- Year:
- 2 003
- Bibliographic source:
- Food Add Contam 20, 1097-1194
- Reference Type:
- publication
- Title:
- Possible mutagenic activity of saccharin
- Author:
- Renner HW
- Year:
- 1 979
- Bibliographic source:
- Experientia 35, 1364-1365
- Reference Type:
- publication
- Title:
- Excretion of cyclohexylamine, a metabolite of cyclamate in human urine
- Author:
- Asahina M et al
- Year:
- 1 971
- Bibliographic source:
- Chem Pharm Bull 19, 628-632
- Reference Type:
- publication
- Title:
- Entero-bacterial formation of cyclohexylamine in rats ingesting cyclamate
- Author:
- Bickel MH et al
- Year:
- 1 974
- Bibliographic source:
- Xenobiotical 4, 425-439
Materials and methods
Results and discussion
Applicant's summary and conclusion
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