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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: individual doses and animal data are not shown

Data source

Reference
Reference Type:
publication
Title:
Range-finding Toxicity data: List VII
Author:
Smyth jr HF, Carpenter ChP, Weil CS, Pozzani UC, Striegel JA, Nycum JS
Year:
1969
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 30, 470-476

Materials and methods

Principles of method if other than guideline:
Different doses of test substance was applied to the shaved skin of male rabbits for 24 hours and observed for mortality for 14 days.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexylamine
EC Number:
203-629-0
EC Name:
Cyclohexylamine
Cas Number:
108-91-8
Molecular formula:
C6H13N
IUPAC Name:
cyclohexanamine
Details on test material:
no further data

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
initial bod weight : 2.5 to 3.5 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Different doses of test substance were applied to the shaved skin of male rabbits for 24 hours. The testsubstance is retained beneath an impervious plasma film.
Duration of exposure:
24 hours
Doses:
individual doses are not given
No. of animals per sex per dose:
4
Control animals:
no
Details on study design:
Different doses of test substance were applied to the shaved skin of male rabbits for 24 hours. The testsubstance is retained beneath an impervious plasma film. The animals are immobilized during the24 hour period, after which the film is removed. the rabbits are caged for the subsequent 14 day observation period. Based upon mortality during a 14-day observation period the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil
Statistics:
the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 275 mg/kg bw
95% CL:
>= 208 - <= 372
Mortality:
Based upon mortality during a 14-day observation period the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil (no further data)
Clinical signs:
no data
Body weight:
no final body weights given
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

Different doses of cyclohexylamine were applied to the shaved skin of male rabbits for 24 hours under occlusive conditions. the LD50 is 275 mg/kg bw (Smyth 1969)

Applicant's summary and conclusion