Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-629-0 | CAS number: 108-91-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: individual doses and animal data are not shown
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding Toxicity data: List VII
- Author:
- Smyth jr HF, Carpenter ChP, Weil CS, Pozzani UC, Striegel JA, Nycum JS
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 30, 470-476
Materials and methods
- Principles of method if other than guideline:
- Different doses of test substance was applied to the shaved skin of male rabbits for 24 hours and observed for mortality for 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Cyclohexylamine
- EC Number:
- 203-629-0
- EC Name:
- Cyclohexylamine
- Cas Number:
- 108-91-8
- Molecular formula:
- C6H13N
- IUPAC Name:
- cyclohexanamine
- Details on test material:
- no further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- initial bod weight : 2.5 to 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Different doses of test substance were applied to the shaved skin of male rabbits for 24 hours. The testsubstance is retained beneath an impervious plasma film.
- Duration of exposure:
- 24 hours
- Doses:
- individual doses are not given
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- Different doses of test substance were applied to the shaved skin of male rabbits for 24 hours. The testsubstance is retained beneath an impervious plasma film. The animals are immobilized during the24 hour period, after which the film is removed. the rabbits are caged for the subsequent 14 day observation period. Based upon mortality during a 14-day observation period the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil
- Statistics:
- the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 275 mg/kg bw
- 95% CL:
- >= 208 - <= 372
- Mortality:
- Based upon mortality during a 14-day observation period the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil (no further data)
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
Different doses of cyclohexylamine were applied to the shaved skin of male rabbits for 24 hours under occlusive conditions. the LD50 is 275 mg/kg bw (Smyth 1969)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
