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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
other: comprehensive reviews
Adequacy of study:
other information

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Cyclohexylamine
Author:
German MAK Commission
Year:
2006
Bibliographic source:
MAK Value Documentation, Vol22 DFG; WILEY Verlag, Weinheim
Reference Type:
review article or handbook
Title:
Cyclohexylamine. Health basedreassessment of administrative occupational exposure limits
Author:
NL HealthCouncil
Year:
2001
Bibliographic source:
Health Council of the Netherlands, The Hague
Reference Type:
review article or handbook
Title:
Toxicological aspects of cyclamate and cycvlohexylamine
Author:
Bopp BA, Sonders RC, Keterson JW
Year:
1986
Bibliographic source:
CRC Crit. Rev. Toxicol. 16, 213-306

Materials and methods

Principles of method if other than guideline:
Comprehensive reviews

Results and discussion

Any other information on results incl. tables

There are many studies available that investigate acute toxicity after parental exposure. Based on all available data the authors discuss the following LD50 values:

LD50 (i.p.)approx. 350 mg/kg for rats and approx. 619 mg/kg for mice; LD50 (s.c.) for mice approx. 1150 mg/kg and LD50(i.v.) for dogs approx. 200 mg/kg

Applicant's summary and conclusion