Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Principles of method if other than guideline:
Method: other: BASF-Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexylamine
EC Number:
203-629-0
EC Name:
Cyclohexylamine
Cas Number:
108-91-8
Molecular formula:
C6H13N
IUPAC Name:
cyclohexanamine
Details on test material:
IUCLID4 Test substance: other TS: as prescribed by chapter 1 BASF AG

Test animals

Species:
rabbit
Details on test animals or test system and environmental conditions:
Dermal application of undiluted test substance to the back of rabbitsfor up to 20 hours and a post exposure observation time of up to 8 days

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
no data
Duration of treatment / exposure:
up to 20 hours
Observation period:
up to 8 days
Number of animals:
no data
Details on study design:
Dermal application of undiluted test substance to the back of rabbitsfor up to 20 hours and a post exposure observation time of 8 days

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: finding after 1 min exposure
Basis:
mean
Time point:
other: 24 hours, 8 days
Reversibility:
other: necrosis, not reverible
Remarks on result:
other: scores were not given
Irritation parameter:
other: finding after 5 min and 15 nin of exposure
Basis:
mean
Time point:
other: 24 hours and 8 days
Reversibility:
other: marked necrosis, not reversible
Remarks on result:
other: scores were not given
Irritation parameter:
other: finding after 20 hours of exposure
Basis:
mean
Time point:
other: 24 hours and 8 days
Reversibility:
other: marked necrosis rounded by significant erythema, not reversible
Remarks on result:
other: scores not given
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
not measured/tested
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
not measured/tested
Irritant / corrosive response data:
see table
Other effects:
no further data

Any other information on results incl. tables

no further data

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Conclusions:
corrosive
Executive summary:

Undiluted test substance was applied to the back of rabbits for up to 20 hours and post exposure observed for up to 8 days. the testsubstance caused necrosis which was noted already 24 hours after an exposure time of 1 min (BASF 1970)