Registration Dossier
Registration Dossier
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EC number: 203-629-0 | CAS number: 108-91-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Principles of method if other than guideline:
- Method: other: BASF-Test
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclohexylamine
- EC Number:
- 203-629-0
- EC Name:
- Cyclohexylamine
- Cas Number:
- 108-91-8
- Molecular formula:
- C6H13N
- IUPAC Name:
- cyclohexanamine
- Details on test material:
- IUCLID4 Test substance: other TS: as prescribed by chapter 1 BASF AG
Constituent 1
Test animals
- Species:
- rabbit
- Details on test animals or test system and environmental conditions:
- Dermal application of undiluted test substance to the back of rabbitsfor up to 20 hours and a post exposure observation time of up to 8 days
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- up to 20 hours
- Observation period:
- up to 8 days
- Number of animals:
- no data
- Details on study design:
- Dermal application of undiluted test substance to the back of rabbitsfor up to 20 hours and a post exposure observation time of 8 days
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: finding after 1 min exposure
- Basis:
- mean
- Time point:
- other: 24 hours, 8 days
- Reversibility:
- other: necrosis, not reverible
- Remarks on result:
- other: scores were not given
- Irritation parameter:
- other: finding after 5 min and 15 nin of exposure
- Basis:
- mean
- Time point:
- other: 24 hours and 8 days
- Reversibility:
- other: marked necrosis, not reversible
- Remarks on result:
- other: scores were not given
- Irritation parameter:
- other: finding after 20 hours of exposure
- Basis:
- mean
- Time point:
- other: 24 hours and 8 days
- Reversibility:
- other: marked necrosis rounded by significant erythema, not reversible
- Remarks on result:
- other: scores not given
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- see table
- Other effects:
- no further data
Any other information on results incl. tables
no further data
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Conclusions:
- corrosive
- Executive summary:
Undiluted test substance was applied to the back of rabbits for up to 20 hours and post exposure observed for up to 8 days. the testsubstance caused necrosis which was noted already 24 hours after an exposure time of 1 min (BASF 1970)
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