Registration Dossier
Registration Dossier
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EC number: 265-198-5 | CAS number: 64742-94-5 A complex combination of hydrocarbons obtained from distillation of aromatic streams. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 165°C to 290°C (330°F to 554°F).
Neurotoxicity
Administrative data
Description of key information
Toluene exposure can produce central nervous system pathology in animals after high oral doses. In humans neuropsychological effects have been reported, particularly when exposures are not well controlled. There was no association noted between either current or long-term (LWAE) toluene exposure and any of the cognitive outcomes measured, with 26ppm the mean current exposure and 45ppm the mean estimated lifetime exposure (Seeber et al, 2004).
Key value for chemical safety assessment
Additional information
There are no specific neurotoxicity data on any of the streams within the Fuel Oils category. Of the specific components toluene and styrene are recognised as having neurotoxic activity. These effects are discussed briefly in the section on repeated dose toxicity (5.6.3).
Justification for classification or non-classification
See section 5.6 for overall classification for repeated dose toxicity.
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