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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998
Report date:
1998

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
no
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Octanoyl chloride
EC Number:
203-891-6
EC Name:
Octanoyl chloride
Cas Number:
111-64-8
Molecular formula:
C8H15ClO
IUPAC Name:
octanoyl chloride
Details on test material:
- Name of test material (as cited in study report): N-OCTANSAEURECHLORID
- Physical state: liquid, colourless
- Analytical purity: 97% (by GC)
- Lot/batch No.: Vers. 62/V
- Stability under test conditions: test substance is sensitive to hydrolysis
- Storage condition of test material: room temperature, exclusion of moisture

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: DR. K. THOMAE GMBH, BIBERACH, D
- Age at study initiation: Young adult animals
- Weight at study initiation: 150-300 g (+-20% of the mean weight)
- Housing: single housing in stainless steel wire mesh cages
- Diet (e.g. ad libitum): KLIBA-LABORDIAET, KLINGENTAMUEHLE AG, KAISERAUGST, SWITZERLAND, AD LIBITUM
- Water (e.g. ad libitum): TAP WATER AD LIBITUM PER DAY
- Acclimation period: at least one week

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 10, 40%

MAXIMUM DOSE VOLUME APPLIED: 5 mL
Doses:
500 and 2000 mg/kg bw
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: RECORDING OF SIGNS AND SYMPTOMS SEVERAL TIMES ON THE DAY OF ADMINISTRATION, AT LEAST ONCE EACH WORKDAY FOR THE INDIVIDUAL ANIMALS. INDIVIDUAL BODY WEIGHTS SHORTLY BEFORE APPLICATION (DAY 0), WEEKLY THEREAFTER AND AT THE END OF THE STUDY (BEFORE FASTING PERIOD). A CHECK FOR ANY DEAD OR MORIEBUND ANIMAL WAS MADE TWICE EACH WORKDAY AND ONCE ON SATURDAYS, SUNDAYS AND ON PUBLIC HOLIDAYS.
- Necropsy of survivors performed: yes
NECROPSY AT THE LAST DAY OF THE OBSERVATION PERIOD. WITHDRAWAL OF FOOD AT LEAST 16 HOURS BEFORE KILLING WITH CO2; THEN NECROPSY WITH GROSSPATHOLOGY EXAMINATION. NECROPSY OF ALL ANIMALS THAT DIED BEFORE AS EARLY AS POSSIBLE.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
no mortality observed
Clinical signs:
other: SIGNS OF TOXICITY NOTED IN THE 2000 MG/KG DOSE GROUP AND IN THE FEMALE RATS OF TUE 500 MG/KG DOSE GROUP COMPRISED IMPAIRED OR POOR GENERAL STATE, DYSPNOEA, APATHY AND STAGGERING. ADDITIONALLY ATAXIA WAS OBSERVED IN 1 MALE ANIMAL OF THE 2000 MG/KG DOSE GRO
Gross pathology:
NO ABNORMALITIES WERE NOTED AT NECROPSY OF ANIMALS SACRIFICIED AT THE END OF THE STUDY.

Applicant's summary and conclusion