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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Description of key information

Accumulation in organisms is not to be expected. 

Key value for chemical safety assessment

Additional information

In accordance with column 2 of REACH Annex IX, the study need not be conducted since the substance has a log Kow ≤ 3. The target substance 2 -(2-aminoethoxy)ethanol (CAS 929 -06 -6) has a calculated log Kow of ‑1.89 (BASF SE, KOWWIN v1.68).  

However, in order to assess the bioaccumulation potential of the test substance, the BCF was calculated with the BCF Baseline estimation model v04.11 (Catalogic v5.14.1.5).

The BCF base-line model estimates the BCF to be 2.69 (log BCF = 0.43) taking all mitigating factors into consideration. The maximum BCF was calculated to be 9.18 (log BCF = 0.963). Mitigating factors like metabolism, molecular size and the water solubility were considered by the model. Metabolism had the highest mitigating effect on the bioaccumulation potential.

According to the OECD 305 technical guidance document, the degree of transformation of the parent is decisive for the effect of metabolism (i.e. the reproduction of subsequent steps is less critical for the prediction of the BCF).

Metabolism and, for a minor part, molecular size reduce the log BCF as estimated by the model. Water solubility and molecular size are discussed within the literature whether certain threshold values are suitable as cut-off criteria for indication of limited bioaccumulation. Regarding molecular size, the PBT working group on hazardous substances discussed a maximum diameter of > 17.4 Å (Comber et al., 2006). However, the mean diameter is lower than the critical value (9.385 Å).



Based on the available information on the log Kow (log Kow = -1.89) and supported by a weight-of-evidence approach from calculated data, it can be concluded that accumulation in organisms is not to be expected.





In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.


According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.


For the assessment of 2 -(2 -aminoethoxy)ethanol (Q)SAR results were used for aquatic bioaccumulation.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.


Therefore, and for reasons of animal welfare, further experimental studies on aquatic bioaccumulation are not provided.