Registration Dossier
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EC number: 213-195-4 | CAS number: 929-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro studies:
2 -(2 -aminoethoxy)ethanol was evaluated for mutagenicity in the Salmonella/microsome preincubation assay using a standard protocol approved by the National Toxicology Program. Doses of 0, 12.5, 25, 50, 100, 500, 2500, 5000 µg/plate were tested in four Salmonella typhimurium strains (TA98, TAl00, TAl535 and TAl537) in the presence and absence of Aroclor-induced rat or hamster liver S9. These tests were negative and the highest ineffective dose level tested in all four Salmonella tester strains under all treatment conditions was 2500 µg/plate (Zeiger et al. 1988; reliability score: 2).
A further AMES-test with 5 strains (TA98, TA100, TA 1535, TA1537 and TA1538) confirmed the negative results (Huntsman, 1982; reliability score: 2). Several other AMES-tests could not be taken into consideration because the test substance was a unknown mixture containing 2-(2-aminoethoxy)ethanol and several other substances (composition confidential, concentration of test substance unclear): In these assays the test substance showed ambiguous results (Chemfirst 1992-1997; reliability:3)
In an In-vitro mammalian cell transformation assay using Mouse BALB/3T3 Cells, both in the absence and presence of metabolic activation (S9 mix) no dose response relationship was observed and transformed foci were not considered to be significant over control dose ranges (Huntsman, 1982; reliability score: 2).
In an unscheduled DNA damage and repair assay with male F344 rat hepatocytes, according to the OECD Guideline 482, no genotoxic potential could be observed (Huntsman, 1982; reliability score: 2).
In vivo studies:
In an in vivo MNT (Huntsman, 2001) the test result was negative for chromosomal aberration.
Short description of key information:
All endpoints are considered addressed. Reliable experimental data are
available with the test substance (AEE) in the Ames Assay, in vitro cell transformation assay
(BALB/3T3 Assay), in vitro Unscheduled DNA Synthesis (UDS) Assay and the in vivo Mouse
Micronucleus Assay. In each case, a guideline method was followed under GLP conditions
which resulted in negative findings.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Two Ames-test (with and without metabolic activation), an in-vitro mammalian cell transformation assay and an in-vitro unscheduled DNA damage and repair assay failed to provide any evidence for a mutagenic effect of 2-(2-aminoethoxy)ethanol.
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