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Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

No effects up to the limit of water solubility for Daphnia magna (OECD 202 part 2)

Key value for chemical safety assessment

Additional information

Since no studies are available for the long-term aquatic invertebrate toxicity of isopropyl oleate (112-11-8), the assessment was based on a study conducted with the structurally most similar substance, for which data is available, Fatty acids, C16-18 and C18 unsaturated isobutyl esters (CAS No. 84988-79-4) as part of a read-across approach. This is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13.

The key study conducted with Fatty acids, C16-18 and C18 unsaturated isobutyl esters (CAS No. 84988-79-4) was performed according to OECD guideline 202 part II and GLP (Wierich, 1995). The test organism Daphnia magna was exposed to the test substance in a semi-static system for 21 days, at loadings of 1 and 100 mg/L. The test solutions were prepared as water accommodated fractions (WAF). At 1 mg/L no mortality and no significant effect on reproduction was observed. At 100 mg/L reproduction was significantly increased compared to the control. Thus, the test substance had no negative effects on reproduction at the tested concentrations, and the NOELR is reported to be ≥ 100 mg/L.

Thus, based on theabove mentioned results, and due to the structural and profile similarities of the two substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological long-term effects on aquatic invertebrates are expected up tothe limit ofwater solubility for isopropyl oleate (CAS No. 112-11-8).