N-isopropyl-N'-phenyl-p-phenylenediamine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Principles of method if other than guideline:

other: acute dermal toxicity study

GLP compliance:

no

Test type:

other: acute dermal toxicity study

Test material

Test material information

Constituent 1

Reference substance name:

N-isopropyl-N'-phenyl-p-phenylenediamine

EC Number:

202-969-7

EC Name:

N-isopropyl-N'-phenyl-p-phenylenediamine

Cas Number:

101-72-4

Molecular formula:

C15H18N2

IUPAC Name:

N1-phenyl-N4-(propan-2-yl)benzene-1,4-diamine

Details on test material:

Santoflex IP

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

corn oil

Duration of exposure:

24 h

Doses:

5010, 7940 mg/kg

No. of animals per sex per dose:

1 to 2 per dose

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 7 940 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Clinical signs

Clinical signs:

other:

Any other information on results incl. tables

Mortality: none

5010 mg/kg: m 0/1, f -, combined: 0/1

7940 mg/kg: m 0/1, f 0/1, combined: 0/2

Clinical signs: Reduced appetite and activity for three to five days.

Gross autopsy:

Survivors (14 days): Viscera appeared normal.