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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Principles of method if other than guideline:
Method: other: in vivo skin irritation study with rabbits
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-isopropyl-N'-phenyl-p-phenylenediamine
EC Number:
202-969-7
EC Name:
N-isopropyl-N'-phenyl-p-phenylenediamine
Cas Number:
101-72-4
Molecular formula:
C15H18N2
IUPAC Name:
N-isopropyl-N'-phenyl-p-phenylenediamine
Details on test material:
Santoflex IP

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: intact and abraded skin tested
Vehicle:
other: moistened with water
Controls:
no
Duration of treatment / exposure:
24 h
Observation period:
7 d
Number of animals:
6

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24, 72 h
Score:
0
Max. score:
8
Reversibility:
other: no effects
Remarks on result:
other: no effects

Any other information on results incl. tables

AVERAGE SCORE
0.0/8.0

Non irritating to rabbit skin

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Remarks:
Migrated information