Registration Dossier
Registration Dossier
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EC number: 204-327-1 | CAS number: 119-47-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: study data do not give sufficient experimental details; in addition, it is ambigous if the test design used is suitable for testing the acute inhalation toxicity
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
Materials and methods
- Principles of method if other than guideline:
- other: acute inhalation toxicity
- GLP compliance:
- no
- Test type:
- other: acute inhalation toxicity
Test material
- Reference substance name:
- 6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
- EC Number:
- 204-327-1
- EC Name:
- 6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
- Cas Number:
- 119-47-1
- Molecular formula:
- C23H32O2
- IUPAC Name:
- 2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- other: different species: rabbit, guinea pig, rat, mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Duration of exposure:
- 4 h
- Concentrations:
- 4 g of the test substance was heated up to 180°C in a 400 l room
- No. of animals per sex per dose:
- 1 rabbit, 1 guinea pig, 2 rats, 4 mice
- Control animals:
- not specified
Results and discussion
Any other information on results incl. tables
Results:
All animals showed effects on respiration (exacerbate breathing) during exposure
Mortality: 1/1 guinea pig; 0/1 rabbit, 0/2 rats; 0/4 mice
After exposure the animals showed breathing difficulties , which were reversible
Applicant's summary and conclusion
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