Registration Dossier
Registration Dossier
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EC number: 204-327-1 | CAS number: 119-47-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Remarks:
- other: repeated dose
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature available
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Environmental health control for the rubber industry, part II
- Author:
- McCormick, W.E.:
- Year:
- 1 972
- Bibliographic source:
- Rubber Chemistry and Technology 45, 627-637
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
Materials and methods
- Principles of method if other than guideline:
- other: repeated dose toxicity
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
- EC Number:
- 204-327-1
- EC Name:
- 6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
- Cas Number:
- 119-47-1
- Molecular formula:
- C23H32O2
- IUPAC Name:
- 2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
- Details on test material:
- migrated data set
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: Wesson oil
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- migrated data set
- Frequency of treatment:
- migrated data set
Doses / concentrations
- Remarks:
- Doses / Concentrations:
400 mg/kg bw/d
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: no
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
no signs of systemic toxicity, severe degrees of skin irritation
Applicant's summary and conclusion
- Executive summary:
Repeated dose application on rabbit skins showed no signs of systemic toxicity, but severe degrees of skin irritation (McCormick 1972).
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