Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically acceptable publication

Data source

Reference
Reference Type:
publication
Title:
Synthesis of Aminoethyl Derivatives of αω-Alkylenediamines and Structure-Activity Relationships for the Polyamine-Bovine Plasma Amine Oxidase System.
Author:
Israel M and Modest EJ
Year:
1971
Bibliographic source:
J Med Chemistry 14: 1042-1047

Materials and methods

Type of study / information:
Antitumour activity
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Growth-inhibitory activity in mammalian cell and bacterial systems, as well as phagocidal action on T-uneven phages, of the naturally occurring polyamines, spermine and spermidine, is known to be the result of conversion of the polyamine to a cytotoxic derivative by means of the enzyme bovine plasma amine oxidase (BPAO). In an attempt to define the geometry of the substrate molecule required for this conversion, a number of polyamine structural variants were examined for growth-inhibitory activity against KB cells (human epidermoid carcinoma) in culture in media supplemented with calf serum (contains BPAO).

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N'-bis(3-aminopropyl)ethylenediamine
EC Number:
234-147-9
EC Name:
N,N'-bis(3-aminopropyl)ethylenediamine
Cas Number:
10563-26-5
Molecular formula:
C8H22N4
IUPAC Name:
(3-aminopropyl)({2-[(3-aminopropyl)amino]ethyl})amine

Results and discussion

Applicant's summary and conclusion