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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically acceptable publication

Data source

Reference
Reference Type:
publication
Title:
Synthesis of Aminoethyl Derivatives of αω-Alkylenediamines and Structure-Activity Relationships for the Polyamine-Bovine Plasma Amine Oxidase System.
Author:
Israel M and Modest EJ
Year:
1971
Bibliographic source:
J Med Chemistry 14: 1042-1047

Materials and methods

Type of study / information:
Antitumour activity
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Growth-inhibitory activity in mammalian cell and bacterial systems, as well as phagocidal action on T-uneven phages, of the naturally occurring polyamines, spermine and spermidine, is known to be the result of conversion of the polyamine to a cytotoxic derivative by means of the enzyme bovine plasma amine oxidase (BPAO). In an attempt to define the geometry of the substrate molecule required for this conversion, a number of polyamine structural variants were examined for growth-inhibitory activity against KB cells (human epidermoid carcinoma) in culture in media supplemented with calf serum (contains BPAO).

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion