Registration Dossier
Registration Dossier
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EC number: 231-626-4 | CAS number: 7659-86-1
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Title:
- Tierexperimentelle Untersuchungen zur Blutdruckwirksamkeit|von Thioglykolsaureisooctylester, Thioglykolsäure und|2-Äthylhexanol
- Author:
- Hollenbach K, Schmidt P and Stremmel D
- Year:
- 1 972
- Bibliographic source:
- Z. Gesamte Hyg., 18, 481-485, and report of|the Zentralinstitut fur Arbeitsmedizin, Berlin, German|Democratic Republic of 19.03.1986.
Materials and methods
- Type of study / information:
- Type of experience: other: Occupational exposure
Test material
- Reference substance name:
- 2-ethylhexyl mercaptoacetate
- EC Number:
- 231-626-4
- EC Name:
- 2-ethylhexyl mercaptoacetate
- Cas Number:
- 7659-86-1
- Molecular formula:
- C10H20O2S
- IUPAC Name:
- 2-ethylhexyl 2-sulfanylacetate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Workers involved in the manufacture of thioglycolic acid 2-ethylhexyl ester frequently complained of headaches, dizziness, fatigue, general weariness and gastrointestinal symptoms. Circulatory stimulants alleviated the syndrome for a short time in some cases, so that the cause was assumed to be a hypotensive effect. The laboratory workers involved in the study of the effects of thioglycolic acid 2-ethylhexyl ester on the blood pressure of rabbits and dogs similarly complained of symptoms of this type and particularly of headaches, after exposure to thioglycolic acid 2-ethylhexyl ester for several days. The laboratory workers were also in contact with thioglycolic acid and ethyl hexanol (no further details provided).
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