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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with national standard methods with acceptable restrictions No data on test design. No data on environmental conditions. No data on tested concentrations.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1974

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Standard acute method with one uninterrupted exposure by inhalation over a short period of time per dose level.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl mercaptoacetate
EC Number:
231-626-4
EC Name:
2-ethylhexyl mercaptoacetate
Cas Number:
7659-86-1
Molecular formula:
C10H20O2S
IUPAC Name:
2-ethylhexyl 2-sulfanylacetate
Details on test material:
- Name of test material (as cited in study report): Thyoglykolsäure-2-äthylhexylester
- Analytical purity: technical quality
- Impurities (identity and concentrations): no relevant purities

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Staatlichen Zentral stelle für Versuchstierzucht und -versorgung, Berlin-Lichtenberg
- Weight at study initiation: 150 to 180 g
- Fasting period before study: no
- Housing: groups of 10
- Diet (e.g. ad libitum): standard food of K type
- Water (e.g. ad libitum): ad libitum



ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C
- Air changes (per hr): dynamic procedure

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
no data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
No data.
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
14 days observation after exposure
Statistics:
No data

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
> 0.51 mg/L air
Exp. duration:
6 h
Mortality:
No mortality until 0.51 mg test substance/L air
Clinical signs:
other: No clinical signs of adverse effects.
Body weight:
Body weight increase was normal.
Gross pathology:
Necropsy at the end of test did not reveal any substance related adverse effects.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LC0 was determined to be higher than 0.51 mg/L (the only tested dose).
Executive summary:

Acute inhalation toxicity of 2-ethylhexyl mercaptoacetate was tested on male and female rats. There was no mortality until 0.51 mg test substance/L air. Animals bodyweight increased normally. Necropsy revealed no adverse effects.