Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Phthalate Esters, The Handbook of Environmental Chemistry
Author:
Staples, C.A.
Year:
2003
Bibliographic source:
Springer Verlag Berlin, Heidelberg, New York
Reference Type:
publication
Title:
Existing Chemical Hazard Assessment Report, di-n-octyl phthalate
Author:
NICNAS
Year:
2008
Bibliographic source:
Australian Government of Health and Ageing NICNAS
Reference Type:
publication
Title:
Phthalate Hazard Compendium, A summary of physicochemical and human health hazard data for 24 ortho-phthalate chemicals
Author:
NICNAS
Year:
2008
Bibliographic source:
Australian Government of Health and Ageing NICNAS

Materials and methods

Results and discussion

Applicant's summary and conclusion

Conclusions:
The materiial is likely to be absorbed after ingestion. Metabolism and excretion will include de-esterification and elimination via the urine.
Executive summary:

The substance is a trimellitate ester with linear C8 and C12 alkyl chains. Experimental data are not available for the assessment of the toxicokinetic properties of the C8 -C12 trimellitate and read-across for toxicokinetic property assessment is therefore a possible approach to characterise toxicokinetic endpoints for the substance. Based on structurally similarity to phthalate esters (with two instead of three carboxylic functions) a similar toxicokinetic behaviour can be expected.

Various reviews of different phthalate esters by the Australian National Industrial Chemicals Notification and Assessment Scheme (NICNAS) are available. The data on the toxicokinetics indicate that phthalates in general are likely to be rapidly absorbed as the monoester from the gut and excreted via the urine.