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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Vinyl 2-ethylhexanoate is practically not toxic by the oral, dermal and inhalation routes of exposure in laboratory animals. The acute rat oral LD50 was 4.76 - 8.30 grams/kg of body weight. The acute rat 4 hr inhalation LC50 was greater than that of substantially saturated vapor. The acute dermal LD50 was > 13.92 grams/kg of body weight.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
4 760 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
13 920 mg/kg bw

Additional information

For males rats the acute oral LD50 = 9.54 ml/kg; For females the LD50 = 5.47 ml/kg; No significant lesions observed from microscopic evaluation. Vinyl 2 -ethylhexanoate is of low acute toxicity to laboratory rats by the oral routes of exposure.

None of the 10 rats male and female exposed to vinyl 2 -ethylhexanoate had any deaths or observed toxic effects. Vinyl 2-ethylhexanoate is practically nontoxic via inhalation of substantially saturated vapor.

Two groups of rats (five males and five females/group) were dermally exposed to Vinyl 2 -ethylhexanoate (16.0 and 8.0 ml/kg per group) under occlusion for 24 hr. The observation period was 14 days.The application of vinyl 2 -ethylhexanoate at doses of 16.0 and 8.0 ml/kg to skin of rat for 24 hr produced an LD50 of >16.0 ml/kg.

Justification for classification or non-classification

No classification and labeling required for acute toxicity hazard based on available data and EU regulatory established limits (EU Directive 67/548/EEC and the CLP, Directive EC 1272/2008 16 December 2008).