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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Not a GLP or O.E.C.D. Testing Guideline study with few details on experimental dosing and results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
GLP compliance:
no
Test type:
fixed concentration procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Vinyl 2-ethylhexanoate
EC Number:
202-297-4
EC Name:
Vinyl 2-ethylhexanoate
Cas Number:
94-04-2
Molecular formula:
C10H18O2
IUPAC Name:
ethenyl 2-ethylhexanoate

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
6 h
Concentrations:
Saturated air
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
A single static ihalation exposure to substantially saturated vapor for 6 hours. The vapor is produced by enclosing approximately 100g of the test material in a sealed 100 to 152 liter animal chamber for approximately 18 hours. A mixing fan periodically agitates the chamber atmosphere to aid in distribution of the vapor. Oxygen is added as need to maintain concentration at 20%.

Results and discussion

Effect levels
Sex:
male/female
Exp. duration:
6 h
Remarks on result:
other: No deaths or toxic effects from substantially saturated vapor.
Mortality:
None
Clinical signs:
other: None
Body weight:
No weight change fromtoxic effect
Gross pathology:
None

Any other information on results incl. tables

Substantially saturated vapor killed 0 of 5 male rats and 0 of 5 female rats after 6 hours of exposure.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Conclusions:
Vinyl 2-ethylhexanoate is practically nontoxic via inhalation of substantially saturated vapor.
Executive summary:

None of the 10 rats male and female exposed to vinyl 2 -ethylhexanoate had any deaths or observed toxic effects. Vinyl 2-ethylhexanoate is practically nontoxic via inhalation of substantially saturated vapor.