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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation is insufficient for assessement
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
K woproci o tokcischnosti cianurowoi kislotui i trioallilisozianurata
Author:
Bidnenko, L.I.
Year:
1969
Bibliographic source:
Gig. Primen. Polim. Mater., Izdelii, Jz Nikh, 299-302

Materials and methods

Principles of method if other than guideline:
The test item was applied to the intact dorsal shaved skin of rats for 2 hours.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 100 - 120 g

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: back (3x3 cm)
Duration of exposure:
2 hours
Doses:
no data
No. of animals per sex per dose:
6 animals per dose
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 2 750 mg/kg bw
Based on:
test mat.
Remarks on result:
other: calculated according to the method by Behrens and Schlosser
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 2 480 mg/kg bw
Based on:
test mat.
Remarks on result:
other: calculated according to the method by Prosorowskj

Any other information on results incl. tables

The test substance is easily soaked into the skin and caused general toxic effects including death of animals. No skin irritation was observed.

Applicant's summary and conclusion