Registration Dossier
Registration Dossier
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EC number: 200-471-4 | CAS number: 60-34-4
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Remarks:
- adsorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- not applicable (QSAR)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- QSAR estimate by an internationally recognized QSAR, within its applicability domain, with correct recognition of the chemical family (hydrazines) and of the compound structure, and based on several experimental data (boiling point, melting point, vapour pressure) which were correctly re-estimated by this QSAR.
- Justification for type of information:
- QSAR prediction
- Principles of method if other than guideline:
- QSAR estimation by KOCWIN v2.00, using two methods (MCI and log Kow) based on following:
- identification data: SMILES= N(N)C, CAS= 000060-34-4 (software recognizes structure, name and ECOSAR Class= hydrazines)
- experimental input: boiling point, melting point, vapour pressure: values as in IUCLID - GLP compliance:
- no
- Remarks:
- QSAR
- Type of method:
- other: QSAR
- Media:
- soil
- Computational methods:
- QSAR methods: MCI and equation using log Kow
- Type:
- log Koc
- Value:
- 1.124
- Remarks on result:
- other: MCI method (QSAR)
- Type:
- log Koc
- Value:
- 0.323
- Remarks on result:
- other: Kow method (QSAR)
- Validity criteria fulfilled:
- not applicable
- Executive summary:
The soil adsorption coefficient of MMH was estimated by QSAR by KOCWIN v2.00 inside EPIsuite v4.00, as Log Koc = 1.124 (using MCI method) or 0.323 (based on log Kow). Therefore adsorption is negligible and enables high mobility in soils.
The relevance of these estimates is confirmed by the coherence of three other estimates with available experimental data.
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the physicochemical properties of the substance indicate that it can be expected to have a low potential for adsorption
Referenceopen allclose all
Description of key information
In agreement with Annex VIII point 9.3.1, the study does not need to be conducted because the substance can be expected to have a negligible potential for adsorption due to its negative experimental log Kow (-1.05) and its extremely high water solubility.
Nevertheless, the soil adsorption coefficient of MMH was estimated as a supportive information, using QSAR by the mean of KOCWIN v2.00 inside EPIsuite v4.00. The following outputs have been found for the substance:
- Log Koc = 1.124 (using MCI method)
- Log Koc = 0.323 (based on log Kow).
Therefore adsorption is negligible and enables high mobility in soils.
The relevance of these estimates is confirmed by the coherence of three other estimates with available experimental data.
Key value for chemical safety assessment
- Koc at 20 °C:
- 1.124
Additional information
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