Registration Dossier
Registration Dossier
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EC number: 265-191-7 | CAS number: 64742-88-7 A complex combination of hydrocarbons obtained from the distillation of crude oil or natural gasoline. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C9 through C12 and boiling in the range of approximately 140°C to 220°C (284°F to 428°F).
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
| Effect | Route | DNEL | Dose Descriptor | Modified Dose Descriptor and Assessment Factors | |
| Acute Exposure | Systemic | Dermal | (a) | ||
| Inhalation | (a) | ||||
| Local | Dermal | (b) | |||
| Inhalation | (a) | ||||
| Long-Term Exposure | Systemic | Dermal | (a) | ||
| Inhalation | (a) | ||||
| Local | Dermal | (b) | |||
| Inhalation | (a) |
a) No hazard identified for this route (data available)
b) The data do not allow setting a DNEL.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
| Effect | Route | DNEL | Dose Descriptor | Modified Dose Descriptor and Assessment Factors | |
| Acute Exposure | Systemic | Dermal | (a) | ||
| Inhalation | (a) | ||||
| Local | Dermal | (b) | |||
| Inhalation | (a) | ||||
| Long-Term Exposure | Systemic | Dermal | (a) | ||
| Inhalation | (a) | ||||
| Oral | 19 mg/kg/24h | 750 mg/kg (NOAEL – 21-week daily oral gavage study based on significant decrease in body weight for females (deemed biologically meaningful) | No modification of dose descriptor was needed since study incorporated daily exposures. A total assessment factor of 40 was applied for inter- and intraspecies differences and for overall duration of exposure. | ||
| Local | Dermal | (b) | |||
| Inhalation | (a) |
a) No hazard identified for this route (data available)
b) The data do not allow setting a DNEL.
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