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EC number: 216-343-6 | CAS number: 1562-00-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Water solubility
- Solubility in organic solvents / fat solubility
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- Flash point
- Auto flammability
- Flammability
- Explosiveness
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- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
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- Stability: thermal, sunlight, metals
- pH
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
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- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study is in accordance to common test guidelines and GLP and therefore rated as reliable without restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium 2-hydroxyethanesulphonate
- EC Number:
- 216-343-6
- EC Name:
- Sodium 2-hydroxyethanesulphonate
- Cas Number:
- 1562-00-1
- Molecular formula:
- C2H6O4S.Na
- IUPAC Name:
- sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate
- Details on test material:
- - Name of test material (as cited in study report): Ethansalz 97/100
- Molecular formula: C2H5O4SNa
- Analytical purity: > =97 % (wt/wt)
- impurities: in small amounts HOCH2CH2-O-CH2CH2SO3Na
- batch no. Op. 36
- production date: 21.05.1986
- physical state: white powder
- Storage condition of test material: darkness at approximately 22°C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG Kastengrund - SPF breed
- Weight at study initiation: 178-181 g (male), 167-174 g (female)
- Age at study initiation: ca. 7 weeks (male), ca. 8 weeks (female)
- Fasting period before study: ca. 16 hours before and 3-4 hours after application
- Diet: Altromin 1324 (Altromin GmbH, Lage/Lippe), ad libitum
- Water: Tap water ad libitum
- Acclimatization period: > 5 days
ENVIRONMENTAL CONDITIONS
- Housing: in fully air-conditioned rooms in Macrolon cages
- Temperature: 22 ± 3°C
- Humidity: 50 ± 20 %
- Photoperiod (hrs light): 12 per day
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- - concentration in vehicle: 50 % (w/v)
- application volume 10 ml/kg bw - Doses:
- The acute oral toxicity was tested only at a dose level of 5000 mg/kg body weight.
- No. of animals per sex per dose:
- 5 male and 5 female rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations once daily / Weighing once weekly
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- Sex: male, Dose: 5000 mg/kg bw, Mortality rate: 0 / 5
Sex: female, Dose: 5000 mg/kg bw, Mortality rate: 1 / 5 - Clinical signs:
- other: - no symptoms of poisoning
- Gross pathology:
- Dissection of rats killed at the end of the observation period revealed no macroscopic findings.
Necropsy revealed no apparent signs of toxicity in the deceased animal and it did not appear to be treatment related.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The median lethal dose of Sodium 2-hydroxyethanesulphonate (LD50) was > 5000 mg per kg body weight. Based on the result of this study Sodium 2-hydroxyethanesulphonate is not subject for labelling and classification requirements according to regulatory requirements.
- Executive summary:
Acute toxicity after single oral application was tested in male and female rats, which received 5000 mg/kg bw. One female and no male died. The necropsy of the deceased female did not reveal any effect and the death was not supposed to be treatment-related. The LD50 value for acute oral toxicity is >5000 mg/kg bw.
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