Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Skin sensitising potential of Sodium 2-hydroxyethanesulphonate was tested in one Local Lymph Node Assay (LLNA) according to OECD test guideline 429. In this assay S.I. of 0.46, 0.48 and 0.56 were determined with the test item at concentrations of 10%, 25% and 50% in ethanol:deionised water, 30:70.

In this assay no EC3 value could be calculated since all S.I. values were below 3.

Migrated from Short description of key information:
Sodium 2-hydroxyethanesulphonate has been tested in one Local Lymph Node Assay to assess the sensitising potential of the test item. In this assay Stimulation Indices (S.I.) below 1 were obtained with test concentrations up to 50% in ethanol:deionised water, 30:70.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

There are no respiratory sensitization properties of the substance known in literature. Beyond this there is no hint of any sensitization property of the compound from the LLNA study. Therefore, it is concluded that the subsance is not a respiratory sensitizer.


Migrated from Short description of key information:
Based on the existing data it is concluded that the substance is not a respiratory sensitizer.

Justification for classification or non-classification

Sodium 2-hydroxyethanesulphonate did not show skin sensitizing properties in the LLNA study according to the current OECD guidelines. Allergic skin reactions or case reports of acute contact dermatitis to Sodium 2-hydroxyethanesulphonate have not been described in the literature. Therefore, the substance does not have to be classified as a skin sensitizer.

A classification concerning respiratory sensitizing properties is not warranted as the classification criteria according to EU regulation 1272/2008 and 67/548 are not met.