Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-343-6 | CAS number: 1562-00-1
- Sodium 2-hydroxyethanesulphonate showed negative results in the study for the induction of gene mutations (bacterial reverse mutation assay) by frameshift or base-pair substitutions with and without metabolic activation. The study was performed with the test strains S. typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538 and E. coli WP2 uvr A. Test concentrations up to the limit concentration of 5000 µg/plate or above (up to 10000 mg/plate) were tested in the experiment. The test compound proved to be not toxic to the bacterial strains.
- Sodium 2-hydroxyethanesulphonate also yielded negative results in an in vitro gene mutation study in mammalian cells in concentrations up to 1500 µg/ml (10 mM) in the presence and absence of metabolic activation.
- Sodium 2-Hydroxyethanesulphonate was assessed for its potential to induce micronuclei in human lymphocyte in vitro. The test item did not induce micronuclei. Therefore, Sodium 2-Hydroxyethanesulphonate is considered to be non-mutagenic in this in vitro micronucleus test when tested up to the highest required concentration (10 mM).
Sodium 2-Hydroxyethanesulphonate was not classified for mutagenicity since this substance did not reveal any mutagenic effect in the bacterial reverse mutation assay in the presence or absence of metabolic activation in concentrations up to 10000 µg/plate, in the in vitro micronucleus test (up to 10 mM) or in the Mouse lymphoma assay in concentrations up to 1500 µg/mL.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again