Registration Dossier
Registration Dossier
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EC number: 932-185-7 | CAS number: 1187742-72-8
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (28 d) for Oncorhynchus mykiss = 0.14 mg/L related to mortality and sublethal effects (measured, similar to OECD 215)
Key value for chemical safety assessment
Additional information
The assessment is based on the data currently available. New studies, based on the category review and the final decisions issued for some of the category substances, which are also relevant for this assessment, are currently being conducted. The hazard assessment with respect to aquatic toxicity will be updated once all ongoing studies have been finalised.
No chronic fish studies on toxic effects of AES (C12 -14, 1 -2.5EO) MIPA (CAS 1187742 -72 -8) are available. Therefore, a read-across approach from a comparable AES (C12 -14, 2EO) Na (CAS 68891 -38 -3) and the pure AES homologue (C14, 2EO) Na (CAS 27731-62-0) is used.
To determine the toxic effect of the AES (C12 -14, 2EO) Na a study similar to OECD guideline 215 was performed (TEGEWA, 1995). In this test juvenile individuals of rainbow trout (Oncorhynchus mykiss) were exposed to different concentrations of AES (C12 -14, 2EO) Na under flow-through conditions. Mortality and growth were determined over 28 days. Related to mortality and sublethal effects a NOEC of 0.14 mg/L (measured) was determined.
This result is supported by a non-GLP study carried out similar to OECD guideline 210, eggs of fathead minnow (Pimephales promelas) were exposed to the pure AES homologue (C14, 2EO) Na (P&G, 2004). Under flow-through conditions a NOEC (28 d) of 0.18 mg/L (measured) was determined. The NOEC based on mortality.
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