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EC number: 204-279-1 | CAS number: 118-82-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From May to November 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study guidelines
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7860 (Water Solubility Generator Column Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Water solubility:
- 0.032 µg/L
- Temp.:
- 20 °C
- pH:
- 7
- Remarks on result:
- other: solubility of the testing substance was 0.0319± 0.00392 μg a.i./L (n = 5, CV = 12.3%).
- Details on results:
- Under the experimental conditions presented, the mean water solubility for AN2 was 0.0319± 0.00392 μg a.i./L (n = 5, CV = 12.3%). The percent difference in calculated solubility for collected samples was 25.1%.
- Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of 4,4'-METHYLENEBIS (2,6-DI-TERT-BUTYLPHENOL) was determined using the generator column method. Under the experimental conditions presented, the mean water solubility for the testing substance was 0.0319 ± 0.00392 μg a.i./L (n = 5, CV = 12.3%). - Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 February 2005-18 March 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline Study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: as cited in US CFR 799.6784
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Water solubility:
- < 0 g/L
- Temp.:
- 20 °C
- pH:
- >= 5.6 - <= 7
- Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubilty of the test material has been determined to be less than 1.0 x 10e-5 g/L of solution at 10.0 + or - 0.5 degree C. - Executive summary:
- Water Solubility.Less
than 1.0 x 10-5g/L of solution at 20±0.5°C,
using the column elution method:
* Method A6 of Commission Directive 92/69/EEC.
* Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
* Method 830.7840 of the OPPTS Guidelines.
* Method 40 CFR 799.6784. - Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: EU method and GLP study.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- < 0 g/L
- Temp.:
- 20 °C
- pH:
- 8.66
- Details on results:
- The water solubility of the test substance was determined as less than the detection limit for the method of analysis, based on the concentration of the lowest calibration standard, i.e. < 2.15 x 10-5 g/l at 20 ºC.
- Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of the test substance was determined as less than the detection limit for the method of analysis, based on the concentration of the lowest calibration standard, i.e. < 2.15 x 10-5 g/l at 20 ºC. - Executive summary:
The water solubility was determined according to EU method A.6 to be less than the detection limit for the method of analysis, based on the concentration of the lowest calibration standard, i.e. < 2.15 x 10 -5 g/L at 20 ºC.
Referenceopen allclose all
Results:
Preliminary Test:
The preliminary estimate of water solubility was <0.457 mg/L.
Definitive Test:
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Solution |
Mean Peak Area |
Standard 10.1 mg/L |
267.173 |
Standard 10.0 mg/L |
277.854 |
Sample 2A |
8.517 |
Sample 2B |
3.415 |
Standard 10.1 mg/L |
275.944 |
Standard 10.0 mg/L |
275.324 |
Sample 3A |
3.565 |
Sample 3B |
0.276 |
Standard 10.1 mg/L |
271.741 |
Standard 10.0 mg/L |
286.113 |
Sample 4A |
3.009 |
Sample 4B |
1.426 |
Standard 10.8 mg/L |
302.535 |
Standard 10.3 mg/L |
285.763 |
Sample 5A |
0.817 |
Sample 5B |
1.056 |
Standard 10.0 mg/L |
248.735 |
Standard 10.1 mg/L |
276.669 |
Sample 6A |
4.060 |
Sample 6B |
2.163 |
Sample 1 was omitted as not enough sample remained for analysis after centrifugation.
The concentration (g/L) of test material in the sample solution is shown in the following table:
Sample Number |
Sampling Time (hour) |
Concentration (g/L) |
Solution pH |
|||
DeterminationA |
DeterminationB |
DeterminationA |
DeterminationB |
DeterminationA |
DeterminationB |
|
1 |
189 |
189.75 |
* |
* |
7.0 |
6.9 |
2 |
211.5 |
211.75 |
1.57 x 10-5† |
6.30 x 10-6 |
6.9 |
6.6 |
3 |
234 |
234.25 |
6.49 x 10-6 |
5.03 x 10 -7 |
6.4 |
6.3 |
4 |
265.75 |
265.75 |
5.48 x 10-6 |
2.60 x 10-6 |
5.6 |
5.8 |
5 |
286.75 |
287 |
1.47 x 10-6 |
1.90 x 10-6 |
5.9 |
5.9 |
6 |
306 |
306.5 |
7.78 x 10-6 |
4.15 x 10-6 |
5.9 |
6.0 |
* Sample 1 not analyzed due to insufficient aliquot after centrifugation. † Sample 2A not included in calculation of overall results. |
||||||
The overall results are shown in the following table:
Determination |
Mean Concentration (g/L) |
A |
<1.0 x 10-5 |
B |
<1.0 x 10-5 |
Overall |
<1.0 x 10-5 |
Validation:
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 20 mg/L. This was satisfactory with a correlation coefficient of 1.000 being obtained. Recovery of analysis of the sample procedure was assessed and proved adequate for the test. Recovery data is shown in the following table:
Nominal concentration(mg/L) |
Recovery range (%) |
Mean recovery (%) |
0.5 |
102-104 |
103 |
0.05 |
92.1-107 |
98.1 |
0.01 |
140-148 |
144 |
Description of key information
Key study: experimental results: GLP study. OECD 105 the water solubility of the test substance was 0.0319± 0.00392 μg a.i./L (n = 5, CV = 12.3%). At 20 deg. C
Key value for chemical safety assessment
- Water solubility:
- 0.032 µg/L
- at the temperature of:
- 20 °C
Additional information
Key study: experimental results: GLP study. OECD 105 the water solubility of the test substance was 0.0319± 0.00392 μg a.i./L (n = 5, CV = 12.3%). At 20 deg. C
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