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EC number: 204-279-1 | CAS number: 118-82-1
Long-term toxicity to fish
Administrative data
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted QSAR model
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: ECSAR model prediction
- Title:
- EPISIUTE model predictions for 4,4'-methylene bis(2,6-di-tertbutyl phenol)
- Author:
- Jacobi S
- Year:
- 2 013
- Bibliographic source:
- US Environmental Protection Agency Office of Pollution Prevention and Toxics and Syracuse Research Corporation. EPI Suite TM 2000-2012
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- QSAR using ECOSAR v 1.11, US, EPA
Trainig data set: polyphenols and baseline toxicity Neutral organic SAR
Test material
- Reference substance name:
- 2,2',6,6'-tetra-tert-butyl-4,4'-methylenediphenol
- EC Number:
- 204-279-1
- EC Name:
- 2,2',6,6'-tetra-tert-butyl-4,4'-methylenediphenol
- Cas Number:
- 118-82-1
- Molecular formula:
- C29H44O2
- IUPAC Name:
- 2,6-di-tert-butyl-4-[(3,5-di-tert-butyl-4-hydroxyphenyl)methyl]phenol
Constituent 1
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.003 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: chronic toxicity estimate QSAR plyphenols duration minimum 14 d
- Remarks on result:
- other: concentration above the solubility limit as predicted by the model
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.038 µg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- other: chronic toxicity estimate QSAR neutral organics duration minimum 14 d
- Remarks on result:
- other: concentration above the solubility limit as indicated by the model
- Details on results:
- Based on Acute to chronic toxixicty ratios of classes of substances. Applicability domain log Kow 8. log Kow used: 8.993. The prediction is on the limit of the applicability domain of the model.
Applicant's summary and conclusion
- Conclusions:
- The model predicts a toxicity level above the solubility limit. This is consistent with the existing experimental data.
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