Registration Dossier

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

An adaptation to the standard data requirements was submitted to address this endpoint. As no significant exposure to the environment is anticipated, and since the substance is not bioavailable (due to its high insolubility), testing for this endpoint is considered unnecessary and is therefore omitted.

Key value for chemical safety assessment

Additional information

A bioaccumulation study by Oshioka (2004) was included as supporting information. The study conducted to GLP standard, in compliance with agreed protocols, with no or minor deviations from standard test guidelines. The study used dispersants to aid solubility, which can impact on the partitioning between the water and fish tissue and hence produce artificial results. The study conducted using a semi-static method rather than the preferred flow through as it was impossible to prepare uniform and stable feed solutions. On these basis, the study was not considered reliable to address the bioaccumulation endpoint.