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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
14.8 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
5
Modified dose descriptor starting point:
NOAEC
Value:
74 mg/m³
Explanation for the modification of the dose descriptor starting point:
Not necessary, because of existing 90 d study with inhalative exposure to rats.
AF for dose response relationship:
1
Justification:
The data of the studies indicate, that the dose-response curve is flat.
AF for differences in duration of exposure:
2
Justification:
Default assessment factor sub-chronic to chronic.
AF for interspecies differences (allometric scaling):
1
Justification:
The relevant toxic effect is a local irritation, differences in the metabolic rate are not relevant.
AF for other interspecies differences:
1
Justification:
Besides a local irritation and its consequences, no specific effects were observed.
AF for intraspecies differences:
5
Justification:
Default assessment factor for intraspecies extrapolation.
AF for the quality of the whole database:
1
Justification:
There exist guideline studies to all relevant toxicological endpoints.
AF for remaining uncertainties:
0.5
Justification:
The data are consistent between the different toxicological studies. Acrylic acid to Magnesium acrylate: AF=0.5 Taking into account the higher molecular weight of Magnesium acrylate (ca. 2 times higher) compared to acrylic acid and besides that the general lower toxicity the DNEL for Magnesium acrylate should be at least two times higher than for acrylic acid.
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
14.8 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
5
DNEL extrapolated from long term DNEL
Modified dose descriptor starting point:
NOAEC
Value:
74 mg/m³

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
14.8 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
5
Dose descriptor:
NOAEC
AF for dose response relationship:
1
Justification:
The data of the studies indicate, that the dose-response curve is flat.
AF for differences in duration of exposure:
2
Justification:
Default assessment factor sub-chronic to chronic.
AF for interspecies differences (allometric scaling):
1
Justification:
The relevant toxic effect is a local irritation, differences in the metabolic rate are not relevant.
AF for other interspecies differences:
1
Justification:
Besides a local irritation and its consequences, no specific effects were observed.
AF for intraspecies differences:
5
Justification:
Default assessment factor for intraspecies extrapolation.
AF for the quality of the whole database:
1
Justification:
There exist guideline studies to all relevant toxicological endpoints.
AF for remaining uncertainties:
0.5
Justification:
The data are consistent between the different toxicological studies. Acrylic acid to Magnesium acrylate: AF=0.5 Taking into account the higher molecular weight of Magnesium acrylate (ca. 2 times higher) compared to acrylic acid and besides that the general lower toxicity the DNEL for Magnesium acrylate should be at least two times higher than for acrylic acid.
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
14.8 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
5
DNEL extrapolated from long term DNEL
Dose descriptor starting point:
NOAEC

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
2.2 mg/kg bw/day
Most sensitive endpoint:
skin irritation/corrosion
Route of original study:
Dermal
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
5
Modified dose descriptor starting point:
LOAEL
Value:
11 mg/kg bw/day
Explanation for the modification of the dose descriptor starting point:
Not necessary, because of existing chronic study with dermal exposure to mice.
AF for dose response relationship:
1
Justification:
The data of the studies indicate, that the dose-response curve is flat.
AF for differences in duration of exposure:
1
Justification:
A study with chronic dermal application is available
AF for interspecies differences (allometric scaling):
1
Justification:
The relevant toxic effect is a local irritation, differences in the metabolic rate are not relevant.
AF for other interspecies differences:
1
Justification:
Besides a local irritation and its consequences, no specific effects were observed.
AF for intraspecies differences:
5
Justification:
Default assessment factor for intraspecies extrapolation.
AF for the quality of the whole database:
2
Justification:
LOAEL/NOEL extrapolation. There exists only a LOAEL in the chronic toxicity study with dermal application.
AF for remaining uncertainties:
0.5
Justification:
The data are consistent between the different toxicological studies. Acrylic acid to Magnesium acrylate: AF=0.5 Taking into account the higher molecular weight of Magnesium acrylate (ca. 2 times higher) compared to acrylic acid and besides that the general lower toxicity the DNEL for Magnesium acrylate should be at least two times higher than for acrylic acid.
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
400 mg/kg bw/day
Most sensitive endpoint:
skin irritation/corrosion
Route of original study:
Dermal
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
5
Modified dose descriptor starting point:
NOAEL
Value:
2 000 mg/kg bw/day
Explanation for the modification of the dose descriptor starting point:
Not necessary, because of existing acute study with Magnesium acrylate with dermal exposure to rats.
AF for dose response relationship:
1
Justification:
The data of the studies indicate, that the dose-response curve is flat.
AF for interspecies differences (allometric scaling):
1
Justification:
The relevant toxic effect is a local irritation, differences in the metabolic rate are not relevant.
AF for other interspecies differences:
1
Justification:
Metabolism is not a driving force for the local effect.
AF for intraspecies differences:
5
Justification:
Default assessment factor for intraspecies extrapolation (worker).
AF for the quality of the whole database:
1
Justification:
There exists a acute dermal toxicity study with Magnesium acrylate.
AF for remaining uncertainties:
1
Justification:
The data are consistent between the different toxicological studies.

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.052 mg/cm²
Most sensitive endpoint:
skin irritation/corrosion
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
5
Dose descriptor:
other: LOAEL: 11 mg/kg bw day, no data on area of application. Assuming 1 cm2 results in 0.26 mg/cm2.
AF for dose response relationship:
1
Justification:
The data of the studies indicate, that the dose-response curve is flat.
AF for differences in duration of exposure:
1
Justification:
A study with chronic dermal application is available
AF for interspecies differences (allometric scaling):
1
Justification:
The relevant toxic effect is a local irritation, differences in the metabolic rate are not relevant.
AF for other interspecies differences:
1
Justification:
Besides a local irritation and its consequences, no specific effects were observed.
AF for intraspecies differences:
5
Justification:
Default assessment factor for intraspecies extrapolation.
AF for the quality of the whole database:
2
Justification:
LOAEL/NOEL extrapolation. There exists only a LOAEL in the chronic toxicity study with dermal application.
AF for remaining uncertainties:
0.5
Justification:
The data are consistent between the different toxicological studies. Acrylic acid to Magnesium acrylate: AF=0.5 Taking into account the higher molecular weight of Magnesium acrylate (ca. 2 times higher) compared to acrylic acid and besides that the general lower toxicity the DNEL for Magnesium acrylate should be at least two times higher than for acrylic acid.
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
25 mg/cm²
Most sensitive endpoint:
skin irritation/corrosion
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
5
Dose descriptor starting point:
other: NOAEL (acute dermal toxicity) = 2000 mg/kg bw per day (application site 4 cm x4 cm)
AF for dose response relationship:
1
Justification:
The data of the study indicate, that the dose-response curve is flat.
AF for interspecies differences (allometric scaling):
1
Justification:
The relevant toxic effect is a local irritation, differences in the metabolic rate are not relevant.
AF for other interspecies differences:
1
Justification:
Metabolism is not a driving force for the local effect.
AF for intraspecies differences:
5
Justification:
Default assessment factor for intraspecies extrapolation (worker).
AF for the quality of the whole database:
1
Justification:
There exists a acute dermal toxicity study with Magnesium acrylate.
AF for remaining uncertainties:
1
Justification:
The data are consistent between the different toxicological studies.

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population