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Registration Dossier
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EC number: 227-177-9 | CAS number: 5698-98-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 14.8 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 74 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Not necessary, because of existing 90 d study with inhalative exposure to rats.
- AF for dose response relationship:
- 1
- Justification:
- The data of the studies indicate, that the dose-response curve is flat.
- AF for differences in duration of exposure:
- 2
- Justification:
- Default assessment factor sub-chronic to chronic.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The relevant toxic effect is a local irritation, differences in the metabolic rate are not relevant.
- AF for other interspecies differences:
- 1
- Justification:
- Besides a local irritation and its consequences, no specific effects were observed.
- AF for intraspecies differences:
- 5
- Justification:
- Default assessment factor for intraspecies extrapolation.
- AF for the quality of the whole database:
- 1
- Justification:
- There exist guideline studies to all relevant toxicological endpoints.
- AF for remaining uncertainties:
- 0.5
- Justification:
- The data are consistent between the different toxicological studies. Acrylic acid to Magnesium acrylate: AF=0.5 Taking into account the higher molecular weight of Magnesium acrylate (ca. 2 times higher) compared to acrylic acid and besides that the general lower toxicity the DNEL for Magnesium acrylate should be at least two times higher than for acrylic acid.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 14.8 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- DNEL extrapolated from long term DNEL
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 74 mg/m³
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 14.8 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- Dose descriptor:
- NOAEC
- AF for dose response relationship:
- 1
- Justification:
- The data of the studies indicate, that the dose-response curve is flat.
- AF for differences in duration of exposure:
- 2
- Justification:
- Default assessment factor sub-chronic to chronic.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The relevant toxic effect is a local irritation, differences in the metabolic rate are not relevant.
- AF for other interspecies differences:
- 1
- Justification:
- Besides a local irritation and its consequences, no specific effects were observed.
- AF for intraspecies differences:
- 5
- Justification:
- Default assessment factor for intraspecies extrapolation.
- AF for the quality of the whole database:
- 1
- Justification:
- There exist guideline studies to all relevant toxicological endpoints.
- AF for remaining uncertainties:
- 0.5
- Justification:
- The data are consistent between the different toxicological studies. Acrylic acid to Magnesium acrylate: AF=0.5 Taking into account the higher molecular weight of Magnesium acrylate (ca. 2 times higher) compared to acrylic acid and besides that the general lower toxicity the DNEL for Magnesium acrylate should be at least two times higher than for acrylic acid.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 14.8 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- DNEL extrapolated from long term DNEL
- Dose descriptor starting point:
- NOAEC
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.2 mg/kg bw/day
- Most sensitive endpoint:
- skin irritation/corrosion
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- Modified dose descriptor starting point:
- LOAEL
- Value:
- 11 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Not necessary, because of existing chronic study with dermal exposure to mice.
- AF for dose response relationship:
- 1
- Justification:
- The data of the studies indicate, that the dose-response curve is flat.
- AF for differences in duration of exposure:
- 1
- Justification:
- A study with chronic dermal application is available
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The relevant toxic effect is a local irritation, differences in the metabolic rate are not relevant.
- AF for other interspecies differences:
- 1
- Justification:
- Besides a local irritation and its consequences, no specific effects were observed.
- AF for intraspecies differences:
- 5
- Justification:
- Default assessment factor for intraspecies extrapolation.
- AF for the quality of the whole database:
- 2
- Justification:
- LOAEL/NOEL extrapolation. There exists only a LOAEL in the chronic toxicity study with dermal application.
- AF for remaining uncertainties:
- 0.5
- Justification:
- The data are consistent between the different toxicological studies. Acrylic acid to Magnesium acrylate: AF=0.5 Taking into account the higher molecular weight of Magnesium acrylate (ca. 2 times higher) compared to acrylic acid and besides that the general lower toxicity the DNEL for Magnesium acrylate should be at least two times higher than for acrylic acid.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 400 mg/kg bw/day
- Most sensitive endpoint:
- skin irritation/corrosion
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 2 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Not necessary, because of existing acute study with Magnesium acrylate with dermal exposure to rats.
- AF for dose response relationship:
- 1
- Justification:
- The data of the studies indicate, that the dose-response curve is flat.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The relevant toxic effect is a local irritation, differences in the metabolic rate are not relevant.
- AF for other interspecies differences:
- 1
- Justification:
- Metabolism is not a driving force for the local effect.
- AF for intraspecies differences:
- 5
- Justification:
- Default assessment factor for intraspecies extrapolation (worker).
- AF for the quality of the whole database:
- 1
- Justification:
- There exists a acute dermal toxicity study with Magnesium acrylate.
- AF for remaining uncertainties:
- 1
- Justification:
- The data are consistent between the different toxicological studies.
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.052 mg/cm²
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- Dose descriptor:
- other: LOAEL: 11 mg/kg bw day, no data on area of application. Assuming 1 cm2 results in 0.26 mg/cm2.
- AF for dose response relationship:
- 1
- Justification:
- The data of the studies indicate, that the dose-response curve is flat.
- AF for differences in duration of exposure:
- 1
- Justification:
- A study with chronic dermal application is available
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The relevant toxic effect is a local irritation, differences in the metabolic rate are not relevant.
- AF for other interspecies differences:
- 1
- Justification:
- Besides a local irritation and its consequences, no specific effects were observed.
- AF for intraspecies differences:
- 5
- Justification:
- Default assessment factor for intraspecies extrapolation.
- AF for the quality of the whole database:
- 2
- Justification:
- LOAEL/NOEL extrapolation. There exists only a LOAEL in the chronic toxicity study with dermal application.
- AF for remaining uncertainties:
- 0.5
- Justification:
- The data are consistent between the different toxicological studies. Acrylic acid to Magnesium acrylate: AF=0.5 Taking into account the higher molecular weight of Magnesium acrylate (ca. 2 times higher) compared to acrylic acid and besides that the general lower toxicity the DNEL for Magnesium acrylate should be at least two times higher than for acrylic acid.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 25 mg/cm²
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- Dose descriptor starting point:
- other: NOAEL (acute dermal toxicity) = 2000 mg/kg bw per day (application site 4 cm x4 cm)
- AF for dose response relationship:
- 1
- Justification:
- The data of the study indicate, that the dose-response curve is flat.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The relevant toxic effect is a local irritation, differences in the metabolic rate are not relevant.
- AF for other interspecies differences:
- 1
- Justification:
- Metabolism is not a driving force for the local effect.
- AF for intraspecies differences:
- 5
- Justification:
- Default assessment factor for intraspecies extrapolation (worker).
- AF for the quality of the whole database:
- 1
- Justification:
- There exists a acute dermal toxicity study with Magnesium acrylate.
- AF for remaining uncertainties:
- 1
- Justification:
- The data are consistent between the different toxicological studies.
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
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