Magnesium acrylate

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

other: Experimental study with acrylic acid (structural analogue) which is used for read-across (see attached read across justification document in IUCLID section 13).

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Relevant methodological deficiencies (only one replicate used, no idenfification of the observed metabolites). Justification for read-across: similar chemical structure (see Cemical Safety Report)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Objective of study:

metabolism

Principles of method if other than guideline:

The urinary metabolites of acrylic acid were compared to those seen previously for acrylamide in an attempt to elucidate the pathways involved in the metabolism of these two compounds in rats. Two male Fischer 344 rats housed in glass metabolism cages were dosed, one by oral gavage and the other by intravenous injection into a jugular cannula with acrylic acid at 50 mg/kg bw. Urine was collected from 0 to 8 hours after administration of the doses and analyzed by ion-exclusion chromatography.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Acrylic acid

EC Number:

201-177-9

EC Name:

Acrylic acid

Cas Number:

79-10-7

IUPAC Name:

acrylic acid

Details on test material:

- Name of test material (as cited in study report): Acrylic acid
- Radiochemical purity (if radiolabelling): 98 % (LSC and UV)
- Specific activity (if radiolabelling): no data
- Locations of the label (if radiolabelling): [2,3-14C]Acrylic acid

Radiolabelling:

yes

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

male

Administration / exposure

Route of administration:

other: gavage and intravenous

Vehicle:

water

Duration and frequency of treatment / exposure:

once

Doses / concentrations

Remarks:

Doses / Concentrations:
50 mg/kg bw

No. of animals per sex per dose / concentration:

1

Control animals:

no

Results and discussion

Metabolite characterisation studies

Metabolites identified:

no

Any other information on results incl. tables

The liquid chromatographic conditions used for the separation of the urinary metabolites of acrylic acid were the same as used previously by the authours for the metabolites of acrylamide (Dow Chemical 1978, unpublished data). Although at least six radioactive peaks were observed, the separation achieved was not optimal due to the low specific activity of the acrylic acid dosing solution used. The observed metabolites were not identified. Except for one major metabolite which was found in chromatograms of both acrylic acid and acrylamide, the peak distribution of urinary metabolites of both substances was dissimilar. Based on these results, the authours suggested that acrylic acid is not a significant intermediate in the acrylamide metabolism but both substances may share a common metabolic intermediate.

Applicant's summary and conclusion

Conclusions:

The results of this study with acrylic acid can be extrapolated to magnesium acrylate.
Please refer to the justification for read across in the Chemical Safety Report.