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Description of key information

Magnesium acrylate:
Skin: In the guidline OECD 402 study no skin irritation at a dosage of magnesium acrylate of 2000 mg/kg body weight was observed.
Eye: OECD Guideline 405 (Acute Eye Irritation / Corrosion) study revealed no irritating effects.
The main and most relevant toxic effects of the reference substance acrylic acid are the corrosive properties. Magnesium acrylate is the magnesium salt of the organic acid acrylic acid. As the study on irritation and corrosion showed, Magesium acrylate has practically no corrosive and only weak irritative properties not leading to classification and labelling.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin corrosion: in vitro / ex vivo
Data waiving:
other justification
Justification for data waiving:
other:
Conclusions:
no skin irritation at a dosage of 2000 mg/kg body weight was observed (OECD 402 study)
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guidline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: Quartier Labaste, F40260 Linxe
- Age at study initiation: 11/12 weeks
- Weight at study initiation: 2.41 - 3.44 kg
- Housing: individual box
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 - 23
- Humidity (%): 30 - 70
- Air changes (per hr): app. 15 per hour
- Photoperiod (hrs dark / hrs light): 12/12
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.1 ml
Duration of treatment / exposure:
72 hours
Observation period (in vivo):
14 days
Number of animals or in vitro replicates:
three
Details on study design:
REMOVAL OF TEST SUBSTANCE: no
Irritation parameter:
maximum mean total score (MMTS)
Basis:
mean
Time point:
other: 24 - 72 hours
Score:
>= 0 - <= 1
Max. score:
1
Reversibility:
fully reversible within: 1-14 days
Irritation parameter:
cornea opacity score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
cornea opacity score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
iris score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
iris score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
iris score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
conjunctivae score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0.7
Max. score:
1
Reversibility:
fully reversible
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
24/48/72 h
Score:
1
Max. score:
1
Reversibility:
fully reversible
Irritation parameter:
conjunctivae score
Basis:
animal #3
Time point:
24/48/72 h
Score:
1
Max. score:
1
Reversibility:
fully reversible
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
0
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0.3
Max. score:
1
Reversibility:
fully reversible
Irritation parameter:
chemosis score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0.3
Max. score:
1
Reversibility:
fully reversible
Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Executive summary:

The test item Magnesium acrylate solution, 46.41%, was instilled as supplied, into one eye of each of three New Zealand rabbits at a dose of 0.1 ml. Ocular examinations were performed on both right and left eyes one hour and 24, 48 and 72 hours after treatment.

The occular reactions observed during the study have been slight to important and totally reversible in the three animals:

-at the conjunctivae level: a moderate to important redness noted 1 hour after the test item instillation and totally reversible between

days 3 and 14,

- moderate chemosis noted 1 hour after the test instillation and totally reversible between days 1 and 2,

- at the iris level: a congestion, noted 1 hour after the test item instillation in one animal and totally reversible on day 1.

According to the criteria for classification, packing and labelling of dangerous substances and preparations in accordance with the EEC Directives 67/548, 2001/59 and 1999/45, the test item Magnesium acrylate solution (46.41%) does not have to be classified.

No symbol or risk phrase is required.

In accordance with the Regulation EC No. 1272/2008 on classification , labelling and packing of substances and mixtures,

the test item does not have to be classified. No signal word or hazard statement is required.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for selection of skin irritation / corrosion endpoint:
In the guidline OECD 402 study no skin irritation at a dosage of magnesium acrylate of 2000 mg/kg body weight was observed.

Justification for selection of eye irritation endpoint:
key study

Justification for classification or non-classification

Magnesium acrylate does not need to be classified according to EC regulation 1272/2008, EEC Directives 67/548 and 1999/45 because no adverse effect were observed (not irritating) in OECD guideline studies assessing skin/eye irritation and corrosion potential.

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