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EC number: 227-177-9 | CAS number: 5698-98-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- other: Experimental study with acrylic acid (structural analogue) which is used for read-across (see attached read across justification document in IUCLID section 13)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Sufficiently documented and scientifically acceptable study. Justification for read-across: similar chemical structure (see Cemical Safety Report)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 477 (Genetic Toxicology: Sex-linked Recessive Lethal Test in Drosophila melanogaster)
- Deviations:
- yes
- Remarks:
- no data on quality assurance
- GLP compliance:
- not specified
- Type of assay:
- Drosophila SLRL assay
Test material
- Reference substance name:
- Acrylic acid
- EC Number:
- 201-177-9
- EC Name:
- Acrylic acid
- Cas Number:
- 79-10-7
- IUPAC Name:
- acrylic acid
- Test material form:
- other: liqid
- Details on test material:
- - Name of test material: Acrylic acid
- Physical state: liquid
- Analytical purity: >99.8%
obtained from Hoechst Celanese Company (Sommerville, NJ, USA)
Constituent 1
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- other: males: Canton-S wild type stock, females: balancer stock "Basc"
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- 5% sucrose solution at pH6
- Details on exposure:
- 1-day-old males, previously starved for 4 hr, were treated in groups of 15 in shell vials (23 x 90 mm) plugged with rayon-fibre balls. The base of each vial was covered with two discs of glass-fibre filter material (SP141) on which was pipetted approximately 1.0 ml of feeding solution containing 2% acrylic acid. Daily for 3 days, the males were transferred to new treatment vials with freshly prepared feeding solution.
- Duration of treatment / exposure:
- 3 days
- Frequency of treatment:
- continously
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2 %
Basis:
other: nominal in 5% sucrose solution at pH 6
- Positive control(s):
- 100 ppm NDMA in 5% sucrose for 24 hr.
Examinations
- Evaluation criteria:
- lethality
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
The Drosophila sex-linked recessive lethal assay is an in vivo mutation assay. In this assay acrylic acid was not mutagenic after oral exposition over 3 days. - Executive summary:
Acrylic acid was tested for induction of sex-linked recessive lethals in Drosophila melanogaster by feeding route. A primary study had established 2% acrylic acid in a 5% sucrose solution at pH 6 as the maximal ingestion level. After 3 days of ingestion of acrylic acid, one lethal was observed in 9070 progeny, in comparison with 5 lethals in 10501 progeny of control males. The mutation frequency after ingestion of acrylic acid was less than concurrent controls in the feeding study.
Therefore it can be concluded with a high degree of confidence that acrylic acid is not mutagenic in this in vivo mutation assay.
This result can be extrapolated to magnesium acrylate.
Please refer to the justification for read across in the Chemical Safety Report.
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