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EC number: 227-177-9 | CAS number: 5698-98-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 53 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- The data are taken from 2 fully reliable studies with acrylic acid - the corresponding organic acid of Magnesium acrylate. In contrast to the free acid Magnesium acrylate has nearly no irritating properties. As the effect levels of acrylic acid are mainly determined by its irritating properties a read across to Magnsium acrylate will overestimate the toxicity. That means the effect levels of Magnesium acrylate should be considerably higher. Therefore the results of the studies with acrylic acid can be taken as a worst case to evaluate Magnesium acrylate. In summary the studies are sufficient for the evaluation of the fertility after oral administration
Additional information
In 2 oral reproduction toxicity studies, a one-generation and a two-generation reproduction toxicity study with administration of Acrylic acind in the drinking water no effects on reproductive function (fertility) were observed. Some signs of postnatal developmental toxicity (retarded body weight gain of the pups) were seen following exposure of the parental generation, however at dose levels that led to reduced food intake and weight gain in the dams. No gross abnormalities were observed in the offspring. A NOEL/fertility of 460 mg/kg bw/d was derived from the guideline 2-generation study in rats according to European Union Risk Assessment Report Acrylic Acid, Volume 28ISBN 92-894-1272-0:
NOEL for reproductive function in rats was 460 mg/kg bw/d (administration in the drinking water).
NOEL for general toxicity was 240 mg/kg bw/d (administration in the drinking water).
NOEL for the F1 generation was 53 mg/kg bw/d (administration in the drinking water).
Justification for selection of Effect on fertility via oral route:
2 key studies: a one-generation and a two-generation study with rats using oral administration via drinking water
Effects on developmental toxicity
Description of key information
Developmental studies with the oral route of administration are not availiable. However, in 2 reproductive toxicity studies in rats with administration of Acrylic acid in the drinking water the postnatal developmental toxicity was investigated. Retarded body weight gain of the pups was seen following exposure of the parental generation, however at dose levels that led to reduced food intake and weight gain in the dams. No gross abnormalities were observed in the offspring.
From these data a NOEL for the offspring of rats of 53 mg/kg bw/d can be derived.
In 2 studies with inhalative exposure of pregnant rats and rabbits no prenatal developmental toxicity was observed, even at concentration levels that produced some signs of maternal toxicity. No specific teratogenic potential could be revealed for dose levels up to and including 360 ppm = 1060 mg/kg bw/d (rats), resp. 225 ppm = 663 mg/kg bw/d (rabbits):
NOEL for maternal toxicity of rabbits was 25 ppm (74 mg/m³).
NOEL (rats) was 360 ppm = 1060 mg/kg bw/d.
NOEL (rabbits) was 225 ppm = 663 mg/m³ (Cited from European Union Risk Assessment Report Acrylic Acid, Volume 28ISBN 92-894-1272-0 (EU, 2002))
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 53 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Cited from European Union Risk Assessment Report Acrylic Acid, Volume 28ISBN 92-894-1272-0
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 663 mg/m³
- Study duration:
- subacute
- Species:
- rabbit
- Quality of whole database:
- The data were taken from 2 fully reliable studies with acrylic acid - the corresponding organic acid of Magnesium acrylate. In contrast to the free acid Magneium acrylate has nearly no irritating properties. As the effect levels of acrylic acid are mainly determined by its irritating properties a data waiving to Magnsium acrylate will overestimate the toxicity. That means the effect levels of Magnesium acrylate should be considerably higher. Therefore the results of the studies with acrylic acid can be taken as a worst case to evaluate Magnesium acrylate. In summary the study is sufficient for the evaluation of the developmetal toxicity after inhalative exposure.
Additional information
Developmental studies with the oral route of administration are not availiable. However, in the 2 reproductive toxicity studies in rats (administration in drinking water) the postnatal developmental toxicity was investigated.
Justification for selection of Effect on developmental toxicity: via inhalation route:
2 key studies, one with rats and another one with rabbits
Justification for classification or non-classification
According to the present database for toxicity for reproduction there are no reasons to classify Acrylic acid as a reproductive toxicant
according to the criteria of regulation (EC) 1272/2008 and EEC Directive 67/548.
This is in line with the European Union Risk Assessment Report Acrylic Acid, Volume 28ISBN 92-894-1272-0 (EU, 2002): " ...
In oral reproductive toxicity studies (rats) no effects on reproductive function (fertility) were observed. ... No prenatal developmental toxicity was observed (rats and rabbits, inhalation), even at concentration levels that produced some signs of maternal toxicity. ... A NOAEL/developmental toxicity of 225 ppm (according to 663 mg/m³) was derived from the developmental toxicity study in rabbits ... According to the present database for toxicity for reproduction there are no reasons to classify acrylic acid as a reproductive toxicant...."
The same holds true for Magnesium acrylate.
Additional information
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