Registration Dossier
Registration Dossier
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EC number: 203-453-4 | CAS number: 107-02-8
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Freshwater fish
60 d NOEC=0.0114 mg/L (measured; basis for effects: mortality of adults, number of spawning, number of eggs per female, number of eggs per spawn, length of offspring and hatchability)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.011 mg/L
Additional information
1. European Union Risk Assessment Report of Acrolein (EU, 2001)
Fresh water
(EU, 2001) literal citation: “In addition to the base set information for fish, also a long-term NOEC-value is available. In a 60-days reproduction study with Pimephales promelas a NOEC-value of 11.4 μg/l is reported (measured value) for effects on mortality of adults, number of spawning, number of eggs per female, number of eggs per spawn, length of offspring and hatchability.”
Marine fish
(EU, 2001) literal citation: “Long-term toxicity data for marine fish species are not available.”
2. Agreement with further international Reports and Studies published after finalisation of the EU Risk Assessment Report 2001
WHO (2002): Acrolein was toxic to the fathead minnow (Pimephales promelas) following a 60-day exposure to 21.8 μg/litre. The survival of the F1 fathead minnow was significantly reduced at 42 μg/litre; the NOEL for F1 survival was estimated to be 11 μg/litre.
3. Substantial disagreements in comparison to further international Reports to European Union Risk Assessment Report 2001
None
4. Additional aspects in further international Reports
None
5. Additional information in newer Studies, not included in the European Union Risk Assessment Report 2001 or further cited international reports
None
6. Conclusions
The lowest reliable long-term fish toxicity study is a 60-days reproduction study with Pimephales promelas. A NOEC-value of 11.4 μg/l is reported (measured value) for effects on mortality of adults, number of spawning, number of eggs per female, number of eggs per spawn, length of offspring and hatchability.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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