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Long-term toxicity to fish

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Description of key information

The high quality chronic freshwater database contains toxicity data towards lead for 6 freshwater fish species (Oncorhynchus mykiss, Salvelinus fontinalis, Pimephales promelas, Lepomis macrochirus, Salvelinus namaycush, Ictalurus punctatus, Salmo salar). No-effect levels for dissolved lead for fish were situated between 18.9 µg Pb/L (Oncorhynchus mykiss; endpoint: scoliosis) and 1558.6 µg Pb/L (Pimephales promelas; endpoint: dry weight)The chronic toxicity database for marine fish contains toxicity data for 1 marine fish (Cyprinodon variegatus). The lowest selected no-effect levels for dissolved lead for this marine fish was 229.6 µg Pb/L (Cyprinodon variegatus; endpoint: dry weight). 

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Additional information

Pyrochlore:

The overall chemical and physiological properties of pyrochlore are principally characterised by a degree of inertness because of the specific synthetic process (calcination at high temperatures, approximately 1000°C), rendering the substance to be of a unique, stable crystalline structure in which the majority of atoms are tightly bound and not prone to dissolution in environmental and physiological media. This has been shown in transformation/dissolution testing for antimony, in which dissolved Sb concentrations were below 27 µg/L (after 7 days at a loading of 0.1g/L) and 2 µg/L (after 28 days at a loading of 1 mg/L); thus implying a solubility of < 0.03% of antimony. Hence, Sb can be considered as not bioavailable and is not regarded concerning toxicological and environmental effects.

On the other hand, lead dissolution levels were much higher (>2.9 mg/L at a loading of 100 mg/L after 7 days at pH 6; 105 µg/L at a loading of 1 mg/L after 28 days at pH 6) and therefore have to be regarded concerning toxicological and environmental aspects. No substance-specific data on the toxicity of pyrochlore are available, so that instead read-across to lead oxide and sparingly soluble lead compounds was conducted

Lead:

The high quality chronic freshwater database contains toxicity data towards lead for 6 freshwater fish species (Oncorhynchus mykiss, Salvelinus fontinalis, Pimephales promelas, Lepomis macrochirus, Salvelinus namaycush, Ictalurus punctatus, Salmo salar). No-effect levels for dissolved lead for fish were situated between 18.9 µg Pb/L (Oncorhynchus mykiss; endpoint: scoliosis) and 1558.6 µg Pb/L (Pimephales promelas; endpoint: dry weight)The chronic toxicity database for marine fish contains toxicity data for 1 marine fish (Cyprinodon variegatus). The lowest selected no-effect levels for dissolved lead for this marine fish was 229.6 µg Pb/L (Cyprinodon variegatus; endpoint: dry weight).