3-methoxypropylamine

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

No data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to

Guideline:

OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)

GLP compliance:

not specified

Vehicle:

not specified

Test organisms (species):

Cyprinus carpio

Details on test organisms:

TEST ORGANISM
- Common name: Carp
- Lipid content: 4.2 %
- Source: Sugishima fish farm, Japan
- Age at study initiation (mean and range, SD):
- Length at study initiation (length definition, mean, range and SD): ca. 10 cm
- Weight at study initiation (mean and range, SD): ca. 30 g
- Weight at termination (mean and range, SD):
- Food: pelleted feed for carp

ACCLIMATION
- Acclimation period: 28 days
- Acclimation conditions (same as test or not): 25 °C +/- 1 °C

Route of exposure:

aqueous

Test type:

flow-through

Test temperature:

25 +/- 2°C

Dissolved oxygen:

6-8 mg/l

Details on test conditions:

TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: glass tanks of 100 litres in volume
- Type of flow-through (e.g. peristaltic or proportional diluter): Aquatron
- Renewal rate of test solution (frequency/flow rate): 200-800 ml/min
- No. of organisms per vessel: 15 - 20

TEST MEDIUM/ WATER PARAMETERSe
- Source/preparation of dilution water: Dilution water used for the test originated from underground water pumped up from the ground of Kurume Research Laboratories.
- Intervals of water quality measurement: twice a week

Nominal and measured concentrations:

0.1, 1.0 mg/L

Key result

Conc. / dose:

1 mg/L

Type:

BCF

Value:

< 0.3 L/kg

Basis:

other: Concentration of test substance in fish, no further data available

Key result

Conc. / dose:

0.1 mg/L

Type:

BCF

Value:

>= 2.7 - <= 3.6 L/kg

Basis:

other: Concentration of test substance in fish, no further data available

Key result

Depuration time (DT):

6 wk

Validity criteria fulfilled:

yes

Conclusions:

The key study (Klimisch 2) of MITI (1996) indicated that the test substance has no potential for bioaccumulation. The study was run according to the OECD 305C guideline. A BCF < 10 L/kg ww was obtained after exposing carp (Cyprinus carpio) to a single concentration of 0.1 and 1 mg/L test substance.

Description of key information

The key study (Klimisch 2) of MITI (1996) indicated that the test substance has no potential for bioaccumulation. The study was run according to the OECD 305C guideline. A BCF < 10 L/kg ww was obtained after exposing carp (Cyprinus carpio) to single concentrations of 0.1 and 1 mg/L test substance.

Additional information

A single study (MITI, 1996) investigating bioaccumulation of test substance in fish (carp, Cyprinus carpio) indicated that the substance has no potential for bioaccumulation. After of exposure to two concentrations (0.1 and 1 mg/L) no test substance could be traced in whole organisms or tissues. The BCF was therefore < 10 L/kg ww. It should be kept in mind that the exposure concentration was quite low compared to concentrations causing toxic effects to aquatic organisms (e.g., acute LC50 of 164 mg/L for golden orfe). Nevertheless, the results of this study confirm what was expected based on the low log Kow of the substance.