Registration Dossier
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EC number: 226-241-3 | CAS number: 5332-73-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- GLP compliance:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Carp
- Lipid content: 4.2 %
- Source: Sugishima fish farm, Japan
- Age at study initiation (mean and range, SD):
- Length at study initiation (length definition, mean, range and SD): ca. 10 cm
- Weight at study initiation (mean and range, SD): ca. 30 g
- Weight at termination (mean and range, SD):
- Food: pelleted feed for carp
ACCLIMATION
- Acclimation period: 28 days
- Acclimation conditions (same as test or not): 25 °C +/- 1 °C - Route of exposure:
- aqueous
- Test type:
- flow-through
- Test temperature:
- 25 +/- 2°C
- Dissolved oxygen:
- 6-8 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: glass tanks of 100 litres in volume
- Type of flow-through (e.g. peristaltic or proportional diluter): Aquatron
- Renewal rate of test solution (frequency/flow rate): 200-800 ml/min
- No. of organisms per vessel: 15 - 20
TEST MEDIUM/ WATER PARAMETERSe
- Source/preparation of dilution water: Dilution water used for the test originated from underground water pumped up from the ground of Kurume Research Laboratories.
- Intervals of water quality measurement: twice a week - Nominal and measured concentrations:
- 0.1, 1.0 mg/L
- Key result
- Conc. / dose:
- 1 mg/L
- Type:
- BCF
- Value:
- < 0.3 L/kg
- Basis:
- other: Concentration of test substance in fish, no further data available
- Key result
- Conc. / dose:
- 0.1 mg/L
- Type:
- BCF
- Value:
- >= 2.7 - <= 3.6 L/kg
- Basis:
- other: Concentration of test substance in fish, no further data available
- Key result
- Depuration time (DT):
- 6 wk
- Validity criteria fulfilled:
- yes
- Conclusions:
- The key study (Klimisch 2) of MITI (1996) indicated that the test substance has no potential for bioaccumulation. The study was run according to the OECD 305C guideline. A BCF < 10 L/kg ww was obtained after exposing carp (Cyprinus carpio) to a single concentration of 0.1 and 1 mg/L test substance.
Reference
Description of key information
The key study (Klimisch 2) of MITI (1996) indicated that the test substance has no potential for bioaccumulation. The study was run according to the OECD 305C guideline. A BCF < 10 L/kg ww was obtained after exposing carp (Cyprinus carpio) to single concentrations of 0.1 and 1 mg/L test substance.
Key value for chemical safety assessment
Additional information
A single study (MITI, 1996) investigating bioaccumulation of test substance in fish (carp, Cyprinus carpio) indicated that the substance has no potential for bioaccumulation. After of exposure to two concentrations (0.1 and 1 mg/L) no test substance could be traced in whole organisms or tissues. The BCF was therefore < 10 L/kg ww. It should be kept in mind that the exposure concentration was quite low compared to concentrations causing toxic effects to aquatic organisms (e.g., acute LC50 of 164 mg/L for golden orfe). Nevertheless, the results of this study confirm what was expected based on the low log Kow of the substance.
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