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EC number: 226-241-3 | CAS number: 5332-73-0
Results dose-range finding test:
Vehicle 80% ethanol: 1.0% dose caused no reaction, 10% dose caused slightly patchy erythema (1/4), slight or confluent or moderate patchy erythema (2/4) and severe erythema (1/4), 50% and 100% doses caused severe erythema.
Vehicle acetone: 1.0% and 2.5% doses caused no reaction, 5.0% dose caused no reaction (1/4) and slightly patchy erythema (3/4), 10% dose caused no reaction (2/4), slightly patchy erythema (1/4) and severe erythema (1/4).
The highest non-irritating dose (max. two animals with slightly patchy erythema) for challenge exposure was chosen to be 5% in acetone. The highest dose to cause mild irritation for induction exposure was chosen to be 5% in 80% ethanol.
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