Registration Dossier
Registration Dossier
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EC number: 203-140-2 | CAS number: 103-74-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985-01-07 - 1985-01-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Directive 79/831, Annex V, Part B : Methods for the determination of toxicity; 4.1.5. Acute Toxicity "Skin Irritation".
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Pyridin-2-ethanol
- IUPAC Name:
- Pyridin-2-ethanol
- Details on test material:
- - Physical state: liquid
- Lot/batch No.: CH 5/1
- Stability under test conditions: stable under the conditions of use
- Other: Safety precautions: Routine hygienic procedures were sufficient to assure personnel health and safety.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Erythema, edema and cumulative score
- Basis:
- animal: #78, #79 and #80
- Time point:
- other: 1h, 24h, 48h and 72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Other effects:
- No other effects have been observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU-GHS
- Conclusions:
- The test article is not irritating under the test conditions.
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