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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

Parent compound isobutyryl chloride and hydrolysis product isobutyric acid: Significant accumulation in organisms is not to be expected.
However, the assessment of the bioaccumulation potential of the parent compound may be of low relevance due to the rapid hydrolysis of the acid chloride in aqueous solutions.

Key value for chemical safety assessment

BCF (aquatic species):
3.16 L/kg ww

Additional information

A study is not required for this tonnage band. Moreover and in accordance with column 2 of Annex IX, the study does not need to be conducted if the substance has a low potential for bioaccumulation (for instance a log Kow ≤ 3). Isobutyryl chloride (CAS 79 -30 -1) has an estimated log Kow of 0.44 (KOWWIN v1.68). The substance decomposes rapidly to form HCl and isobutyric acid (CAS 79 -31 -2). The experimental log Kow of 0.94 (Sangster 1993) for the hydrolysis product isobutyric acid does not indicate a significant potential for bioaccumulation.

Parent compound isobutyryl chloride:

The BCF value was calculated using EPISuite v4.10 SRC BCFBAF v3.01. The obtained BCF value was 3.16 L/kg ww (log BCF = 0.50).

The obtained BCF value indicates that no significant accumulation in organisms is expected.

However, the calculation is of low relevance, as the acid chloride decomposes in aqueous solutions within 10 minutes.

Hydrolysis product isobutyric acid:

The BCF value was calculated using EPISuite v4.10 SRC BCFBAF v3.01. The obtained BCF value was 3.16 L/kg ww (log BCF = 0.50).

The obtained BCF value indicates that no significant accumulation in organisms is expected.