Registration Dossier
Registration Dossier
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EC number: 201-194-1 | CAS number: 79-30-1
Endpoint summary
Administrative data
Description of key information
Isobutyryl chloride was found to be highly corrosive to the skin and eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In a skin irritation test comparable to OECD guideline 404, isobutyryl chloride was applied undiluted to the skin of Vienna White rabbits for 1, 5, 15 minutes (two animals per treatment duration) under occlusive conditions (BASF AG, 1969). Observations at 24 hours and 8 days post treatment were reported. Application for 1 minute caused erythema and edema (score of 3) and after 8 days necrosis with flake off in 1 animal and anaemia in the other animal were observed. In animals exposed to the test substance for 5 and 15 minutes severe necrosis up to muscle tissue was observed at 24 hours and crust formation with bleeding cracks after 8 days. Isobutyryl chloride was judged highly corrosive to skin.
In an eye irritation test comparable to OECD guideline 405, 50 µL of the test substance was applied to the conjunctival sac of the eyes of 2 Vienna White rabbits (BASF AG, 1969). Observations after 1 and 24 hours and 8 days were reported. Corrosive effects on the eyeball, edges of eyelids and eye mucosa were observed after 1 hour. Erythema, edema, cloudy eyes, iritis, foul secretion from the eyes, corrosion and bleeding of eye mucosa and partial corrosion of the eye lid edges were observed after 24 hours. After 8 days, erythema, cloudy eyes, crusts on the eyelids and staphyloma were observed. Cauterization was observed at all time points. Isobutyryl chloride was judged highly corrosive to eyes.
Effects on skin irritation/corrosion: highly corrosive
Effects on eye irritation: highly corrosive
Justification for classification or non-classification
Based on the available data, isobutyryl chloride needs to be classified as corrosive to the skin and as to cause risk of serious damage to eyes according to Directive 67/548/EEC (C, R35) and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 (Category 1A, assigned H314).
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