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EC number: 201-194-1 | CAS number: 79-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Method: Before OECD Guideline 404 was established in 1982, skin irritation was tested using an internal method (BASF test). White Vienna rabbits were used. Usually, 2 animals were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions. An application site of 2.5 X 2.5 cm was covered with the liquid or powdered and moistened test substance. After the application time, the skin was washed with water which sometimes contained a mild detergent (e.g. Lutrol (50%)). The animals were observed 7 to 8 days and skin changes were recorded on working days. The report usually describes findings after 24 hours and at the end of the observation period.
- GLP compliance:
- no
Test material
- Reference substance name:
- Isobutyryl chloride
- EC Number:
- 201-194-1
- EC Name:
- Isobutyryl chloride
- Cas Number:
- 79-30-1
- Molecular formula:
- C4H7ClO
- IUPAC Name:
- 2-methylpropanoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): Isobuttersäurechlorid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 1, 5 and 15 minutes and 20 hours
- Observation period:
- 8 days
- Number of animals:
- 2 per treatment duration
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm (patch test)
REMOVAL OF TEST SUBSTANCE:
- After the application time, the skin was washed with water.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: erythema score 1 min exposure
- Basis:
- mean
- Time point:
- other: 24 h - 8 d
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: after 8 days necrosis with flake off in 1 animal, anaemia in the other
- Irritation parameter:
- other: edema score 1 min. exposure
- Basis:
- mean
- Time point:
- other: 24 h - 8 d
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: after 8 days necrosis with flake off in 1 animal, anaemia in the other
- Irritation parameter:
- other: effects 5 min exposure
- Basis:
- mean
- Time point:
- other: 24 h - 8 d
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: severe necrosis up to muscle tissue at 24 h; crust formation with bleeding cracks after 8 days
- Irritation parameter:
- other: effects 15 min. exposure
- Basis:
- mean
- Time point:
- other: 24 h - 8 d
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: severe necrosis up to muscle tissue at 24 h; crust formation with bleeding cracks after 8 days
- Irritant / corrosive response data:
- Due to the severe skin effects, an application time of 20 hours was not tested.
Applicant's summary and conclusion
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information
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