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Registration Dossier
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EC number: 201-194-1 | CAS number: 79-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Before OECD Guideline 405 was established, eye irritation was tested using an internal method (BASF test). White Vienna rabbits were used. Usually 50µl or mg of the test substance were applied to the conjunctival sac of one eye of 2 animals. The non- or saline-treated adjacent eye served as a control. In studies with solids, talcum powder was used as a control. The animals were observed several times on the treatment day and up to 7 or 8 days afterwards, and findings were recorded on working days. The eyes were not washed out after 24 hours as specified in OECD Guideline 405, which could be critical for solids which thus remained on the cornea for several days, causing mechanical damage, which would probably be less severe if it had been washed out after 1 day. The report usually describes findings after 1 and 24 hours, and at the end of the 8-day observation period.
- GLP compliance:
- no
Test material
- Reference substance name:
- Isobutyryl chloride
- EC Number:
- 201-194-1
- EC Name:
- Isobutyryl chloride
- Cas Number:
- 79-30-1
- Molecular formula:
- C4H7ClO
- IUPAC Name:
- 2-methylpropanoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): Isobuttersäurechlorid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye
- Amount / concentration applied:
- 50 µl
- Duration of treatment / exposure:
- single application, no washing was performed
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: findings 1 hour after application
- Time point:
- other: 1 h
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive effects on the eyeball, edges of eyelids and eye mucosa
- Irritation parameter:
- other: findings 24 hours after application
- Time point:
- other: 24 h
- Reversibility:
- not reversible
- Remarks on result:
- other: erythema, edema, cloudy eyes, iritis, foul secretion from the eyes, corrosion and bleeding of eye mucosa, partial corrosion of eye lid edges
- Irritation parameter:
- other: findings after 8 days
- Time point:
- other: 8 d
- Reversibility:
- not reversible
- Remarks on result:
- other: erythema, cloudy eyes, crusts on the eyelids, staphyloma
- Irritation parameter:
- other: cauterization
- Time point:
- other: 1 and 24 h, 8 d
- Reversibility:
- not reversible
- Remarks on result:
- other: cauterization was observed at all time points
Applicant's summary and conclusion
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information
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