4-methylmorpholine

Vapour pressure

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2011-11-14 - 2011-11-23

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

static method

Specific details on test material used for the study:

- Name of test material (as cited in study report): Jeffcat NMM
- Physical state: Liquid
- Analytical purity: 99.54%
- Purity test date: 01-06-2007
- Lot/batch No.: LL077604

Key result

Temp.:

20 °C

Vapour pressure:

22.7 mBar

Remarks on result:

other: The result is the mean of 3 runs

The sample for runs 1 and 2 was vacuumed down over 5.5 hours. For run 3, the sample was vacuumed down over a day and a half, with similar results observed. To minimise loss of material during degassing, the evacuation of the static glassware and test material was carried out at -30°C.

The three runs were performed over a temperature range of -10 °C to 51 °C. Vapour pressure curves were constructed (R=0.9983, 0.9961 and 0.9980) and the vapour pressure at 20 °C interpolated from the curves.

The results obtained from all three analyses were within 2%. Therefore the mean of all three determinations was reported.

Conclusions:

The vapour pressure of the substance has been reported as 22.7 mbar (at 20°C).

Reference 2

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Reason / purpose for cross-reference:

reference to same study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

GLP compliance:

no

Type of method:

dynamic method

Remarks:

under nitrogen

Specific details on test material used for the study:

Name of test material (as cited in study report): Methylmorpholine
Analytical purity: 99.9 % (Aldrich)

Temp.:

17.6 °C

Vapour pressure:

20.1 hPa

Remarks on result:

other: measured

Temp.:

20 °C

Vapour pressure:

23.06 hPa

Remarks on result:

other: intrapolated

temperature   vapour pressure 
t/°C          hPa

17.58         20.09 
24.90         30.14 
34.80         50.22 
41.75         70.25 
49.54         100.22 
66.21         199.85 
77.05         299.84 
91.81         499.40 
102.29        699.44
114.25        999.90

The regression of the results leads with a
mean deviation of 0.15 % to the following equation:
ln (p/bar) = 9.4919 - 3150.39 / (217.56 + t/°C)

Conclusions:

In a non-GLP supporting study, the vapour pressure was determined to be 2.306 kPa at 20 °C.

Description of key information

The vapour pressure of the test substance was determined in a GLP study according to test method EC A.4 to be 2.27 kPa at 20 °C, following the static method (Younis, 2011).

Key value for chemical safety assessment

Vapour pressure:

2.27 kPa

at the temperature of:

20 °C

Additional information

In addition, in a non-GLP supporting study (BASF AG, 2000), the vapour pressure was determined to be 2.306 kPa at 20 °C. Results of both studies are in good agreement.