4-methylmorpholine

Hydrolysis

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

hydrolysis

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Reference 2

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Remarks:

Based on hydrolysis study performed with 4-ethylmorpholine

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Original GLP report not available. Only summary available in freely available OECD SIDS IUCLID4 file.

Justification for type of information:

As the substance does not contain any molecular groups that can react with water, no testing needs to be performed. But an assumption can be made based on the experimental results from a study performed with a structural analogue (4-ethylmorpholine). Justification for this read-across approach is included in section 13.

Reason / purpose for cross-reference:

read-across source

Preliminary study:

Based on the results for the substance, 4-ethylmorpholine, 4-methylmorphine is also not expected to be hydrolysable (half-time > 1 year).

Transformation products:

not measured

pH:

4

Temp.:

25 °C

DT50:

> 1 yr

Remarks on result:

hydrolytically stable based on preliminary test

Remarks:

Based on read-across from structural analogue

pH:

7

Temp.:

25 °C

DT50:

> 1 yr

Remarks on result:

hydrolytically stable based on preliminary test

Remarks:

Based on read-across from structural analogue

pH:

9

Temp.:

25 °C

DT50:

> 1 yr

Remarks on result:

hydrolytically stable based on preliminary test

Remarks:

Based on read-across from structural analogue

Validity criteria fulfilled:

not specified

Conclusions:

According to the available data, the related substance 4-ethylmorpholine is not hydrolysable (half-time > 1 year). The same is assumed to be correct for the test substance.

Reference 3

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

No data

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Original GLP report not available. Only summary available in freely available OECD SIDS IUCLID4 file.

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

GLP compliance:

yes

Preliminary study:

No degradation was observed in all pH conditions and therefore the chemical is stable in water (half-life is more than one year at 25 degree C.

Transformation products:

no

pH:

4

Temp.:

25 °C

DT50:

> 1 yr

pH:

7

Temp.:

25 °C

DT50:

> 1 yr

pH:

9

Temp.:

25 °C

DT50:

> 1 yr

Initial and final concentrations (mg/L) ------------------------------- Initial Final pH4 99.9 99.0, 99.6 pH7 102 98.3, 98.9 pH9 101 103, 100 ------------------------------- No degradation was observed in all pH conditions and therefore the chemical is stable in water (half-life is more than one year at 25 degree C.

Validity criteria fulfilled:

not specified

Conclusions:

According to the available summary, 4-ethylmorpholine is not hydrolysable (half-time > 1 year).

Description of key information

The substance does not contain molecular groups that can react with water and is considered to be hydrolytically stable. Therefore no testing is performed.

Additional information

The assumption that the substance can be considered stable in water is further supported with a read-across study performed with a structural analogue (4-ethylmorpholine), which was determined to be not hydrolysable and has a half-time > 1 year.