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EC number: 269-133-1 | CAS number: 68187-89-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Acid chlorides, coco
- EC Number:
- 269-133-1
- EC Name:
- Acid chlorides, coco
- Cas Number:
- 68187-89-3
- Molecular formula:
- variable
- IUPAC Name:
- dodecanoyl chloride; tetradecanoyl chloride
- Reference substance name:
- Fatty acids, coco, chlorinated
- EC Number:
- 307-160-3
- EC Name:
- Fatty acids, coco, chlorinated
- Cas Number:
- 97553-06-5
- IUPAC Name:
- 97553-06-5
- Reference substance name:
- Cocoyl chloride
- IUPAC Name:
- Cocoyl chloride
- Reference substance name:
- 96/239
- IUPAC Name:
- 96/239
- Details on test material:
- - Name of test material (as cited in study report): Kokosfettsaeurechlorid)
- Batch No.: Vers. 148/U
- Physical state: clear liquid, yellowish
- Analytical purity: 99.5 % (by GC)
- Expiration date of the lot/batch: not reported
- Stability under test conditions: confirmed by the analytical report 98L00389 as stated in the 1st amendment
- Storage condition of test material: at room temperature under exclusion of moisture and oxygen (nitrogen atmosphere)
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach (Germany)
- Age at study initiation: young adult
- Weight at study initiation: 3.84 - 4.00 kg
- Housing: single
- Diet: Kliba Labordiaet 341 (Klingentalmuehle AG, Kaiseraugst, CH) ca. 130 g per day
- Water: tap water ca. 250 mL per day
- Acclimatization: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/ 12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 15 d
- Number of animals:
- 3 (males only)
- Details on study design:
- TEST SITE
- Area of exposure: upper third of the back or flanks
- Type of wrap if used: Idealbinde, Pfaelzische Verbandstoff-Fabrik, Kaiserslautern, Germany, and Fixomull stretch (adhesive fleece), Baiersdorf AG, Hamburg, Germany
REMOVAL OF TEST SUBSTANCE
- Washing: Lutrol and Lutrol/Water 1:1
SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 15 d
- Remarks on result:
- other: partially severe scaling observed; see table for details
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 15 d
- Remarks on result:
- other: see table for details
Any other information on results incl. tables
Exposition: |
4 h |
|||
Animal |
Reading |
Erythema |
Edema |
Symptoms |
1 |
1 h |
3 |
2 |
Erythema and edema extending beyond the area of exposure |
2 |
1 h |
3 |
1 |
Erythema and edema extending beyond the area of exposure |
3 |
1 h |
3 |
1 |
Erythema and edema extending beyond the area of exposure |
1 |
24 h |
4 |
2 |
Erythema and edema extending beyond the area of exposure |
2 |
24 h |
4 |
2 |
Erythema and edema extending beyond the area of exposure |
3 |
24 h |
4 |
2 |
Erythema and edema extending beyond the area of exposure |
1 |
48 h |
4 |
2 |
Erythema and edema extending beyond the area of exposure |
2 |
48 h |
4 |
2 |
Erythema and edema extending beyond the area of exposure |
3 |
48 h |
4 |
3 |
Erythema and edema extending beyond the area of exposure |
1 |
72 h |
4 |
2 |
Erythema and edema extending beyond the area of exposure |
2 |
72 h |
4 |
3 |
Erythema and edema extending beyond the area of exposure |
3 |
72 h |
4 |
3 |
Erythema and edema extending beyond the area of exposure |
1 |
8 d |
4 |
1 |
Erythema and edema extending beyond the area of exposure |
2 |
8 d |
2 |
1 |
Erythema and edema extending beyond the area of exposure, superficial scabbing |
3 |
8 d |
2 |
1 |
Erythema and edema extending beyond the area of exposure, superficial scabbing |
1 |
15 d |
1 |
0 |
Erythema and severe scaling extending beyond the area of exposure |
2 |
15 d |
0 |
0 |
Severe scaling extending beyond the area of exposure |
3 |
15 d |
1 |
0 |
Erythema and scaling extending beyond the area of exposure |
mean |
24 - 72 h |
4.00 |
2.33 |
|
Applicant's summary and conclusion
- Executive summary:
The study was performed according to OECD guideline 404 and GLP requirements and is reliable without restrictions. A cloth (2.5 x 2.5 cm) soaked with 0.5 mL of unchanged test substance was applied on the clipped skin of three rabbits under semiocclusive conditions. After 4 h the test substance was washed away. Application of the test substance for 4 h caused severe erythema, which were not fully reversible in 2/3 animals and slight to moderate edema which were fully reversible within 15 d. Partially severe scaling was observed.
Conclusion
Following the conditions of the test, cocoyl chloride has to be considered as irritating to the skin
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