Registration Dossier
Registration Dossier
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EC number: 203-813-0 | CAS number: 110-89-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The substance is with high probability acutely not harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Remarks:
- Leuciscus idus; test performed with pH-adjustment
- Effect concentration:
- > 100 mg/L
Additional information
The key study, a test according to DIN 38 412 ("Bestimmung der Wirkung von Wasserinhaltsstoffen auf Fische - Fischtest (L15)"), was performed with Leuciscus idus over 96h by BASF AG (1987, report no. 10F0180/875094). The non-GLP study was consistent with all validity criteria of the guideline. Test concentrations were not analytically verified in the static toxicity test. However, from an available acute toxicity study on aquatic invertebrates, conducted with analytical monitoring and recovery rates from 91 to 108 % (BASF SE, 2013, 50E0108/09X103), it can be concluded that piperidine is rather stable in static test systems for at least 48 hours. Moreover, the stability of piperidine in the test medium is considered to be stable over the exposure period based on a sufficient water solubility, a low Henry's Law constant of 1.74 Pa m³/mol (HENRYWIN v3.20, EPI Suite v 4.11) and a low adsorption potential (log Kow = 1.18, EPIWin calculation, BASF SE, 2011; log Koc = 2.3 at pH 5 to 8, calculated according to Franco&Trapp, BASF SE, 2021).
The 96 -h LC50 was determined to be 68.12 mg/L (geometric mean, nominal, not pH-adjusted). All fish died in the highest test concentration of 100 mg/L without pH-adjustment, while there was no mortality observed after the pH-adjustment of the highest test concentration (100 mg/L).
The result is supported by a fish embryo test similar to OECD 236 with Danio rerio. The 48-h LC50 was determined to be 110 mg/L (nominal, not pH-adjusted; Brust, 2001).
In conclusion, the test substance is considered to be acutely not harmful to fish after pH-adjustment.
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