Piperidine

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing in patients and chemical analysis - application to cases from rubber gloves

Author:

Kaniwa M, Isama K, Nakamura A, Kantoh H, Hosono K, Itoh M, Shibata K, Usuda T, Asahi K, Osada T, Matsunaga K, Uleda H

Year:

1994

Bibliographic source:

Contact Dermatitis, 31, 65 -71

Materials and methods

Type of sensitisation studied:

skin

Study type:

case report

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Five cases of allergic contact dermatitis from rubber gloves were investigated using a combination of patch testing in patients and chemical analysis of causative rubber products by gas chromatography (GC) and high-performance liquid chromatography (HPLC).

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Piperidine

EC Number:

203-813-0

EC Name:

Piperidine

Cas Number:

110-89-4

Molecular formula:

C5H11N

IUPAC Name:

piperidine

Specific details on test material used for the study:

- Name of test material (as cited in study report): piperidine
no further data

Method

Type of population:

other: patients with allergic contact dermatitis

Subjects:

- Number of subjects exposed: 4
- Sex: 3 males, one female
- Age: 31, 38, 49, and 51 years
- Race: no data

Clinical history:

ophthalmologist, used surgical gloves: itchy eruption, thereafter, edema, infiltrative erythema and serious eruption appeared on fingers and hands;
gilder: developed contact dermatitis on the hands and arms, sensitive to a brand of rubber work gloves, and to surgical rubber gloves not used before;
nurse: contact dermatitis on the hands, arms and face, sensitive to brands of surgical rubber gloves;
surgeon: contact dermatitis on the hands and forearms, sensitive to surgical rubber gloves.

Controls:

No data

Route of administration:

dermal

Results and discussion

Results of examinations:

Piperidine was confirmed analytical as an ingredient of the rubber material (rubber accelerators) of rubber gloves.
In the patch test performed with piperidine two of the four patients were hypersensitive to piperidine.
Result of the patch test:
- One case showed a positive reaction on day 2 and 3;
- One case on day 3.
- One case showed no positive reaction to the test item.
- No data about the sensitivity to the test item was obtained for one case.

The authors noticed that in addition to other ingredients in rubber gloves, piperidine, which occurs in the quantities up to several 0.3 to 2.5 mg per g should be considered as a cause of allergic contact dermatitis.