Registration Dossier
Registration Dossier
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EC number: 203-813-0 | CAS number: 110-89-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 23, 95-107
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Treatment of the rabbit skin was performed using a method closely to the one-day cuff method according to Draize, JH et al., 1944 (Methods for Study of Irritation and Toxicity of Substances Applied Topically to the Skin and Mucous Membranes. J. Pharmacol. Exp. Therap. 82, 377)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Piperidine
- EC Number:
- 203-813-0
- EC Name:
- Piperidine
- Cas Number:
- 110-89-4
- Molecular formula:
- C5H11N
- IUPAC Name:
- piperidine
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Piperidine
- Analytical purity: no data
no further data
Test animals
- Species:
- rabbit
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg
ENVIRONMENTAL CONDITIONS
- no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: entire clipped trunk
- Type of wrap if used: impervious plastic film.
TREATMENT
- The animals are immobilized during the 24 hour exposure period. Afterwards the film is removed and the rabbits are caged.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not reported.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 20 mL/kg - Duration of exposure:
- 24 hours
- Doses:
- no data
- No. of animals per sex per dose:
- 4 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 275 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The original value: 0.32 (0.23 - 0.43) mL/kg was converted to mg/kg body weight using the density of 0.86 g/cm³.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
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