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Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
no

Study design

Analytical monitoring:
yes
Details on sampling:
Analytical monitoring on initial solution and for each sampling time.
- Preliminary test: 0h, 2.4h, and 120h (pH4.0 and 7.0-50°C) and 0h and 2.4h (pH 9.0-50°C)
- Test 1 (pH 7.0-50°C): 0, 3, 4.5, 5.5, 6.5, 7.5 and 9h
- Test 2 (pH 7.0): 0, 2 and 4.25h (61°C) ; 0, 1 and 2h (72°C)
Buffers:
3 buffer solutions: pH 4.0, pH 7.0 and pH 9.0; pH checked before used

Results and discussion

Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
pH:
7
Temp.:
50 °C
DT50:
8.71 h
pH:
7
Temp.:
72 °C
DT50:
1.1 h
pH:
7
Temp.:
25
DT50:
131 h
Remarks on result:
other: extrapolation

Any other information on results incl. tables

pH

T ˚C

t1/2

4.0

25

> 1 year

7.0

25

131 h  (extrapolation)

9.0

unstable

 

Applicant's summary and conclusion

Conclusions:
- Thiofestermet hydrolytically stable at pH 4.0 (T1/2 > 1year at 25°C)
- Thiofestermet hydrolytically unstable at pH 7.0 (T1/2 =131h at 25°C)
- Thiofestermet hydrolytically unstable at pH 9.0